Synthetic Route of 10310-21-1, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 10310-21-1, Name is 2-Amino-6-chloropurine, SMILES is NC1=NC(Cl)=C2NC=NC2=N1, belongs to piperidines compound. In a article, author is Tarasova, Olga A., introduce new discover of the category.
2-Amino-5-(cyanomethylsulfanyl)-1H-pyrroles from Propargylamines, Isothiocyanates, and Bromoacetonitrile by One-Pot Synthetic Protocol
Tertiary propargylamines (such as N,N-dialkylpropargylamines, N-propargylpyrrolidine, -piperidine, and -morpholine), isothiocyanates, and bromoacetonitrile have been shown to be readily available building blocks for the highly selective one-pot construction of rare-functionalized pyrroles, namely so far inaccessible 1-substituted 2-amino-5-(cyanomethylsulfanyl)-1H-pyrroles, in up to 92 % yield. This highly efficient and operationally simple approach includes the initial formation of lithium but-2-ynimidothioate (adduct of monolithiated propargylamine and isothiocyanate), its transformation into potassium buta-2,3-dienimidothioate under the action of the t-BuOK/DMSO system (through acetylene-allene isomerization and the exchange by cations), intramolecular cyclization into potassium thienylamide (at <= 15 degrees C), followed by its re-cyclization into potassium pyrrolylsulfide at a higher temperature (45-60 degrees C), and the final S-alkylation of the latter with bromoacetonitrile. The total reaction time is 45-60 min. Synthetic Route of 10310-21-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 10310-21-1 is helpful to your research.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem