Chemistry is an experimental science, Computed Properties of C11H20N2O3, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 388077-74-5, Name is 1-Boc-2-piperidinamide
Prolyl oligopeptidases cleave peptides on the carboxy side of internal proline residues and their inhibition has potential in the treatment of human brain disorders. Using our docking program FITTED, we have designed a series of constrained covalent inhibitors, built from a series of bicyclic scaffolds, to study the optimal shape required for these small molecules. These structures bear nitrile functional groups that we predicted to covalently bind to the catalytic serine of the enzyme. Synthesis and biological assays using human brain-derived astrocytic cells and endothelial cells and human fibroblasts revealed that these compounds act as selective inhibitors of prolyl oligopeptidase activity compared to prolyl-dipeptidyl-aminopeptidase activity, are able to penetrate the cells and inhibit intracellular activities in intact living cells. This integrated computational and experimental study shed light on the binding mode of inhibitors in the enzyme active site and will guide the design of future drug-like molecules.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Computed Properties of C11H20N2O3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 388077-74-5, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H18348N – PubChem