One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 3040-44-6, Name is 1-(2-Hydroxyethyl)piperidine, formurla is C7H15NO. In a document, author is El-Maghraby, Awatef, introducing its new discovery. Recommanded Product: 3040-44-6.
Synthesis, Characterization and In silico Molecular Docking Studies of Novel Chromene Derivatives as Rab23 Inhibitors
THE Rab23 protein overexpression has a Well-validated role in variety of human cancers. Therefore, the present research aimed to identify new Rab23 protein inhibitor candidates using computational based drug design methodology. A novel series of chromeno[2,3-b] pyridine derivatives has been synthesized by the cyclocondensation of 2-amino-3-cyano-4H-chromenes with cyclohexanone and cyclopentanone in ethanolic piperidine solution. The 2-amino-4H-chromenes were obtained using one pot multicomponent condensation of resorcinol; malononitrile and aromatic aldehydes in the presence in ethanolic piperidine solution. All newly synthetic compounds were characterized by spectral analysis IR. NMR and MS and elemental analysis techniques. The best binding modes of chromene derivatives Were evaluated via molecular (locking studies and binding energy calculations, using PyRx tool. The study has shown that the pyran and pyridine moieties interact favorably with the binding site of target protein, providing the mechanism of action against human sapiens Rab23 protein.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem