Synthesis, characterization, crystal structures, and the biological evaluation of 2-phenylthiazole derivatives as cholinesterase inhibitors was written by Shi, Da-Hua;Song, Meng-qiu;Ma, Xiao-Dong;Su, Jia-Bin;Wang, Jing;Wang, Xiu-Jun;Liu, Yu-Wei;Liu, Wei-Wei;Si, Xin-Xin. And the article was included in Journal of Chemical Research in 2021.HPLC of Formula: 1126-09-6 This article mentions the following:
Four 2-phenylthiazole derivatives I [R = 4-methylpiperazin-1-yl, 2-morpholin-4-yl-Et, 3,5-dimethylpiperidin-1-yl, etc.] were synthesized, characterized and evaluated as cholinesterase inhibitors. The structures of the 2-phenylthiazole derivatives were confirmed by 1H and 13C NMR spectroscopy, single-crystal X-ray diffraction studies, and Hirshfeld surfaces anal. Hirshfeld surface anal. of the prepared compounds showed C-H路路路O intermol. interactions. The cholinesterase inhibition activities of the synthesized compounds were tested by Ellman’s method. Compound I [R = 3,5-dimethylpiperidin-1-yl] showed the best acetylcholinesterase inhibition activity with an IC50 value of 8.86渭M and the best butyrylcholinesterase inhibition activity with an IC50 value of 1.03渭M. A docking study demonstrated that the same compound interacted with the catalytic anionic site and peripheral anionic site of acetylcholinesterase and the catalytic anionic site of butyrylcholinesterase. In the experiment, the researchers used many compounds, for example, Ethyl piperidine-4-carboxylate (cas: 1126-09-6HPLC of Formula: 1126-09-6).
Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.HPLC of Formula: 1126-09-6
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem