Quality Control of (S)-Piperidin-3-amine dihydrochloride. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-Piperidin-3-amine dihydrochloride, is researched, Molecular C5H14Cl2N2, CAS is 334618-07-4, about A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore. Author is Shi, Yihui; Park, Jaehyeon; Lagisetti, Chandraiah; Zhou, Wei; Sambucetti, Lidia C.; Webb, Thomas R..
The splicing of pre-mRNA is a critical process in normal cells and is deregulated in cancer. Compounds that modulate this process have recently been shown to target a specific vulnerability in tumors. We have developed a novel cell-based assay that specifically activates luciferase in cells exposed to SF3B1 targeted compounds, such as sudemycin D6. This assay was used to screen a combined collection of approved drugs and bioactive compounds This screening approach identified several active hits, the most potent of which were CGP-74514A and aminopurvalanol A, both have been reported to be cyclin-dependent kinases (CDKs) inhibitors. We found that these compounds, and their analogs, show significant cdc2-like kinase (CLK) inhibition and clear structure-activity relationships (SAR) at CLKs. We prepared a set of analogs and were able to ‘dial out’ the CDK activity and simultaneously developed CLK inhibitors with low nanomolar activity. Thus, we have demonstrated the utility of our exon-skipping assay and identified new mols. that exhibit potency and selectivity for CLK, as well as some structurally related dual CLK/CDK inhibitors.
There is still a lot of research devoted to this compound(SMILES：Cl.Cl.N[C@H]1CCCNC1)Quality Control of (S)-Piperidin-3-amine dihydrochloride, and with the development of science, more effects of this compound(334618-07-4) can be discovered.
Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem