Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 144230-52-4, is researched, SMILESS is FC1(F)CCNCC1.[H]Cl, Molecular C5H10ClF2NJournal, Article, Journal of Medicinal Chemistry called Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase, Author is Ernst, Justin T.; Thompson, Peggy A.; Nilewski, Christian; Sprengeler, Paul A.; Sperry, Samuel; Packard, Garrick; Michels, Theodore; Xiang, Alan; Tran, Chinh; Wegerski, Christopher J.; Eam, Boreth; Young, Nathan P.; Fish, Sarah; Chen, Joan; Howard, Haleigh; Staunton, Jocelyn; Molter, Jolene; Clarine, Jeff; Nevarez, Andres; Chiang, Gary G.; Appleman, Jim R.; Webster, Kevin R.; Reich, Siegfried H., the main research direction is flavagline analog preparation antitumor activity lipophilicity; structure activity flavagline analog antitumor lipophilicity; Zotatifin design synthesis antitumor lipophilicity; eukaryotic initiation factor 4A RNA helicase inhibitor flavagline analog.Quality Control of 4,4-Difluoropiperidine hydrochloride.
Dysregulation of protein translation is a key driver for the pathogenesis of many cancers. Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a critical component of the eIF4F complex, which regulates cap-dependent protein synthesis. The flavagline class of natural products (i.e., rocaglamide A) has been shown to inhibit protein synthesis by stabilizing a translation-incompetent complex for select mRNAs (mRNAs) with eIF4A. Despite showing promising anticancer phenotypes, the development of flavagline derivatives as therapeutic agents has been hampered because of poor drug-like properties as well as synthetic complexity. A focused effort was undertaken utilizing a ligand-based design strategy to identify a chemotype with optimized physicochem. properties. Also, detailed mechanistic studies were undertaken to further elucidate mRNA sequence selectivity, key regulated target genes, and the associated antitumor phenotype. This work led to the design of eFT226 (Zotatifin), I, a compound with excellent physicochem. properties and significant antitumor activity that supports clin. development.
This compound(4,4-Difluoropiperidine hydrochloride)Quality Control of 4,4-Difluoropiperidine hydrochloride was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem