Frustrated Lewis Acid/Bronsted Base Catalysts for Direct Enantioselective 伪-Amination of Carbonyl Compounds was written by Shang, Ming;Wang, Xiaoxu;Koo, Seung Moh;Youn, Jennifer;Chan, Jessica Z.;Yao, Wenzhi;Hastings, Brian T.;Wasa, Masayuki. And the article was included in Journal of the American Chemical Society in 2017.HPLC of Formula: 79-55-0 This article mentions the following:
A method for enantioselective direct 伪-amination reaction catalyzed by a sterically “frustrated” Lewis acid/Bronsted base complex is disclosed. Cooperative functioning of the Lewis acid and Bronsted base components gives rise to in situ enolate generation from monocarbonyl compounds Subsequent reaction with hydrogen-bond activated dialkyl azodicarboxylates delivers 伪-aminocarbonyl compounds in high enantiomeric purity. In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0HPLC of Formula: 79-55-0).
1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.HPLC of Formula: 79-55-0
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem