Serrano, Catherine M. published the artcileUnifying the Aminohexopyranose- and Peptidyl-Nucleoside Antibiotics: Implications for Antibiotic Design, Safety of tert-Butyl piperidin-4-ylcarbamate, the main research area is tuberculosis antiretroviral amicetin prokaryotic translation inhibitor; amicetin; antibiotic; blasticdin S; ribosome; translation inhibitor.
In search of new anti-tuberculars compatible with anti-retroviral therapy we re-identified amicetin as a lead compound Amicetin’s binding to the 70S ribosomal subunit of Thermus thermophilus (Tth) has been unambiguously determined by crystallog. and reveals it to occupy the peptidyl transferase center P-site of the ribosome. The amicetin binding site overlaps significantly with that of the well-known protein synthesis inhibitor balsticidin S. Amicetin, however, is the first compound structurally characterized to bind to the P-site with demonstrated selectivity for the inhibition of prokaryotic translation. The natural product-ribosome structure enabled the synthesis of simplified analogs that retained both potency and selectivity for the inhibition of prokaryotic translation.
Angewandte Chemie, International Edition published new progress about 70S ribosome. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Safety of tert-Butyl piperidin-4-ylcarbamate.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem