Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Application In Synthesis of Methyl 2-piperidinecarboxylate, Which mentioned a new discovery about 41994-45-0
Coumarins are the important class of naturally occurring heterocyclic compounds. Activities like antioxidant, antibacterial, anti-inflammatory, and anticancer have been reported for coumarin derivatives. Present work details the synthesis of substituted coumarin-4-pyrrolones as well as coumarin-4-acetyl amino acids and their DHODH inhibitory activity, which is a dual target for malaria and cancer. Coumarin-4-acetic acids (2a?c) were coupled with different methyl esters of alpha-amino acids (3) giving rise to corresponding coumarin-4-acetyl amino acid methyl esters (4a?o), which on hydrolysis under basic condition underwent cyclization forming substituted dihydropyrrole-2-ones (5a?i), dihydroindolizine-3-ones (5j?l), and dihydropyrrolizin-3-one (5m?o). Acidic hydrolysis of the compounds (4a?o) yielded corresponding coumarin-4-acetyl amino acids (6a?f). The docking study was performed with the protein 4IGH (obtained from PDB) using Surflex?Dock module. The newly synthesized compounds were tested for DHODH inhibitory activity using Brequinar as the standard. Compound 6b showed remarkable inhibition compared with the standard, and the other compounds with terminal COOH showed moderate inhibition.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Application In Synthesis of Methyl 2-piperidinecarboxylate, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 41994-45-0
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7104N – PubChem