Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， HPLC of Formula: C5H9ClN2O2, Which mentioned a new discovery about 24666-56-6
The invention discloses a method for the preparation of amine to that, which belongs to the field of organic synthesis. Through to 2 – methyl – 3 – nitro-benzoic acid methyl ester and 3 – N – benzyloxy carbonyl – L – glutamine as the starting material, 2 – methyl – 3 – nitro-benzoic acid methyl ester after bromo reaction, to obtain the important intermediate 2 – bromomethyl – 3 – nitro-benzoic acid methyl ester. 3 – N – benzyloxy carbonyl – L – glutamine in under the catalytic action of the cyclization reaction, generating 3 – N – benzyloxycarbonyl amino – 2, 6 – dioxopiperidin, amino deprotected to produce 3 – amino – 2, 6 – piperidine dione hydrohalide salt, then with 2 – bromomethyl – 3 – nitro-benzoic acid methyl ester by the ammonolysis reaction to obtain 3 – (4 – nitro – 1 – oxo – 1, 3 – ISO-Indol – 2 – yl) piperidine – 2, 6 – dione, by reduction reaction to that amine. The route has the low cost of raw materials, easy post treatment, the yield and the like, so that the amine to greatly reduce the production cost of the raw material. This invention is a convenient, efficient and suitable for industrial production of synthetic method to that amine. (by machine translation)
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Reference：
Piperidine – Wikipedia,
Piperidine | C5H9491N – PubChem