Photoredox activation of carbon dioxide for amino acid synthesis in continuous flow was written by Seo, Hyowon;Katcher, Matthew H.;Jamison, Timothy F.. And the article was included in Nature Chemistry in 2017.Synthetic Route of C13H17NO2 This article mentions the following:
Although carbon dioxide (CO2) is highly abundant, its low reactivity has limited its use in chem. synthesis. In particular, methods for carbon-carbon bond formation generally rely on two-electron mechanisms for CO2 activation and require highly activated reaction partners. Alternatively, radical pathways accessed via photoredox catalysis could provide new reactivity under milder conditions. Here we demonstrate the direct coupling of CO2 and amines via the single-electron reduction of CO2 for the photoredox-catalyzed continuous flow synthesis of 伪-amino acids. By leveraging the advantages of utilizing gases and photochem. in flow, a com. available organic photoredox catalyst effects the selective 伪-carboxylation of amines that bear various functional groups and heterocycles. The preliminary mechanistic studies support CO2 activation and carbon-carbon bond formation via single-electron pathways, and we expect that this strategy will inspire new perspectives on using this feedstock chem. in organic synthesis. In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidine-2-carboxylic acid (cas: 21319-53-9Synthetic Route of C13H17NO2).
1-Benzylpiperidine-2-carboxylic acid (cas: 21319-53-9) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Synthetic Route of C13H17NO2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem