On October 29, 2020, Scully, Stephen S.; Laplaca, Derek; Pelly, Rachel; Parmar, Rubina Giare; Maetani, Micah published a patent.Application of 357935-97-8 The title of the patent was Preparation of ionizable amine lipids and lipid nanoparticles. And the patent contained the following:
Ionizable amine lipids of formula I [X1 = O, (substituted) NH, bond; X2 = alkylene; X3 = CO, bond; R1 = H, Me; R2, R3 = alkyl; R2X2N = heterocyclyl; R2R3N = heterocyclyl; Y1 = alkylene; Y2 = CH2CH=CH, CO-OCH2CH=CH, CO-O; n = 0-3; R4 = alkyl; Z1 = alkylene, bond; Z2 = CO-O, absent; R5, R6 = alkyl, alkoxy; W = methylene, bond; R7 = H, Me] are prepared which are useful for the delivery of biol. active agents, for example delivering biol. active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions Thus, II was prepared, and had editing efficiency of 23.74% at 0.1 mg/kg, 58.48% at 0.3 mg/kg and 73.6% at 1 mg/kg in mice liver. The experimental process involved the reaction of 1-Ethylpiperidin-4-amine dihydrochloride(cas: 357935-97-8).Application of 357935-97-8
The Article related to lipid nanoparticle ionizable amine lipid preparation, Biomolecules and Their Synthetic Analogs: Prostaglandins and Other Arachidonic Acid Cascade Substances, Thromboxanes, Fatty Acids and other aspects.Application of 357935-97-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem