Schwaid, Adam G. published the artcileDevelopment of a selective activity-based probe for glycosylated LIPA, Synthetic Route of 959918-19-5, the main research area is lysosomal acid lipase glycosylation activity probe; Activity based protein profiling; Glycosylation; LAL; LIPA; Lysosomal acid lipase; Serine hydrolase.
Loss of LIPA activity leads to diseases such as Wolman’s Disease and Cholesterol Ester Storage Disease. While it is possible to measure defects in LIPA protein levels, it is difficult to directly measure LIPA activity in cells. In order to measure LIPA activity directly we developed a LIPA specific activity based probe. LIPA is heavily glycosylated although it is unclear how glycosylation affects LIPA activity or function. Our probe is specific for a glycosylated form of LIPA in cells, although it labels purified LIPA regardless of glycosylation.
Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 959918-19-5 belongs to class piperidines, name is 3-Ethynylpiperidine hydrochloride, and the molecular formula is C7H12ClN, Synthetic Route of 959918-19-5.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem