Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis was written by Scalacci, Nicolo;Brown, Alistair K.;Pavan, Fernando R.;Ribeiro, Camila M.;Manetti, Fabrizio;Bhakta, Sanjib;Maitra, Arundhati;Smith, Darren L.;Petricci, Elena;Castagnolo, Daniele. And the article was included in European Journal of Medicinal Chemistry in 2017.Category: piperidines This article mentions the following:
The neuroleptic drug thioridazine was recently repositioned as possible anti-tubercular drug. Thioridazine showed anti-tubercular activity against drug resistant mycobacteria but it is endowed with adverse side effects. A small library of thioridazine derivatives was designed through the replacement of the piperidine and phenothiazine moieties, with the aim to improve the anti-tubercular activity and to reduce the cytotoxic effects. Among the resulting compounds, the indole derivative 1-(2-(piperidin-2-yl)ethyl)-1H-indole showed an antimycobacterial activity significantly better than thioridazine and a cytotoxicity 15-fold lower. In the experiment, the researchers used many compounds, for example, tert-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate (cas: 118811-03-3Category: piperidines).
tert-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate (cas: 118811-03-3) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Category: piperidines
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem