Determination of cyproheptadine hydrochloride in pure and pharmaceutical forms : a spectrophotometric study was written by Sayanna;Veeraiah, T.;Reddy, Ch. Venkata Ramana. And the article was included in Oriental Journal of Chemistry in 2015.Application of 969-33-5 This article mentions the following:
Siimple and sensitive extractive spectrophotometric methods have been described for the determination of Cyproheptadine hydrochloride (CPH) in pure form and in pharmaceutical formulations. The developed methods involved formation of colored chloroform extractable ion-pair complexes of the CPH with tri-Ph methane dyes viz., bromothymol blue (BTB), bromocresol green (BCG) and bromocresol purple (BCP) in acidic medium. The extracted complexes showed absorbance maxima at 419, 419 and 405nm with use of the above dyes, resp. Beer’s law is obeyed in the concentration ranges 3.0-25, 2.5-22.5 and 1.5-25μg/mL with BTB, BCG and BCP resp. The stoichiometry of the complex is found to be 1:1 in each case. The effect of concentration of dye, pH and interference of excipients have been studied and optimized. The limit of detection and limit of quantification have been determined for three methods. The methods are applied to the determination of CPH in com. tablets and results of anal. are validated statistically through recovery studies also the methods are validated as per the guidelines of ICH. In the experiment, the researchers used many compounds, for example, 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5Application of 969-33-5).
4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Application of 969-33-5
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem