Sawai, Yasuhiro published the artcileProcess for the Preparation of an Amorphous, Peptide-like Diabetes Drug: Approach to a Chromatography-Free Process, Category: piperidines, the publication is Organic Process Research & Development (2010), 14(5), 1110-1117, database is CAplus.
A manufacturing process suitable for large-scale production of the peptide-like amorphous compound N-((2R)-1-{(3R)-6-chloro-3-[(dimethylamino)methyl]-3,4-dihydroquinolin-1(2H)-yl}-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-1-[(1-methyl-1H-indol-2-yl)carbonyl]piperidine-4-carboxamide (I) as a drug for treating diabetes has been developed. The first kilogram quantities of I were prepared via a single-chromatog. process that employed recyclable cation-exchange resin chromatog. for an amorphous intermediate (2R)-2-amino-1-[(3R)-6-chloro-3-[(dimethylamino)methyl]-3,4-dihydroquinolin-1(2H)-yl]-3-(1H-indol-3-yl)-propan-1-one (II). We have also developed a chromatog.-free process that involves a combination purification of extraction of II with crystallization of II·0.25H3PO4·0.5H2O. The latter process afforded amorphous compound I with >98% purity by HPLC area anal., the same quality as that provided by the former process.
Organic Process Research & Development published new progress about 35661-58-6. 35661-58-6 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-((9H-Fluoren-9-yl)methyl)piperidine, and the molecular formula is C19H21N, Category: piperidines.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem