New μ-opioid receptor agonists with a phenoxyacetic acid moiety was written by Sato, Susumu;Komoto, Teruo;Kanamaru, Yoshihiko;Kawamoto, Noriyuki;Okada, Tomomi;Kaiho, Terurnitsu;Mogi, Kinichi;Morimoto, Shinichi;Umehara, Norimitsu;Koda, Tadayuki;Miyashita, Akira;Sakamoto, Takao;Niino, Yasuhiro;Oka, Tetsuo. And the article was included in Chemical & Pharmaceutical Bulletin in 2002.Synthetic Route of C12H17NO This article mentions the following:
New μ-opioid receptor (MOR) agonists containing 4-hydroxypiperidine, piperidine and piperazine moieties were synthesized and evaluated to find a peripheral opioid analgesic. Among the synthesized compounds, I showed the highest agonist potency on the MOR in an isolated guinea-pig ileum preparation, and it also had selectivity to the human MOR expressed in Chinese hamster ovary (CHO)-K1 cells compared with the same types of δ- and κ-opioid receptors. In addition, compound I showed 10 times more potent MOR agonist activity than loperamide. Furthermore, compound I showed a peripheral analgesic activity in the rat. In the experiment, the researchers used many compounds, for example, 4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8Synthetic Route of C12H17NO).
4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Synthetic Route of C12H17NO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem