Sargent, Brendon T. published the artcileCobalt-Catalyzed Aminocarbonylation of Alkyl Tosylates: Stereospecific Synthesis of Amides, Name: tert-Butyl piperidin-4-ylcarbamate, the main research area is amide stereospecific synthesis cobalt catalyzed aminocarbonylation unactivated alkyl tosylate; alkyl tosylates; aminocarbonylation; cobalt; homogenous catalysis; synthetic methods.
Metal-catalyzed aminocarbonylation is a standard approach for installing amide functionality in chem. synthesis. Despite broad application of this transformation using aryl or vinyl electrophiles, there are few examples involving unactivated aliphatic substrates. Furthermore, there are no stereocontrolled aminocarbonylations of alkyl electrophiles known. Herein, we report a stereospecific aminocarbonylation of unactivated alkyl tosylates for the synthesis of enantioenriched amides. This cobalt-catalyzed transformation uses a remarkably broad range of amines and proceeds with excellent stereospecificity and chemoselectivity.
Angewandte Chemie, International Edition published new progress about Acylation. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Name: tert-Butyl piperidin-4-ylcarbamate.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem