Development of an L-band resonator optimized for fast scan EPR imaging of the mouse head was written by Samouilov, Alexandre;Komarov, Denis;Petryakov, Sergey;Iosilevich, Arkadiy;Zweier, Jay L.. And the article was included in Magnetic Resonance in Medicine in 2021.Recommanded Product: 4-Oxo-tempo This article mentions the following:
To develop a novel resonator for high-quality fast scan ESR (EPR) and EPR/NMR co-imaging of the head and brain of mice at 1.25 GHz. Resonator dimensions were scaled to fit the mouse head with maximum filling factor. A single-loop 6-gap resonator of 20 mm diameter and 20 mm length was constructed. High resonator stability was achieved utilizing a fixed position double coupling loop. Sym. mutually inverted connections rendered it insensitive to field modulation and fast scan. Coupling adjustment was provided by a parallel-connected variable capacitor located at the feeding line at λ/4 distance. To minimize radiation loss, the shield around the resonator was supplemented with a planar conductive disk that focuses return magnetic flux. Coupling of the resonator loaded with the mouse head was efficient and easy. This resonator enabled high-quality in vivo 3D EPR imaging of the mouse head following i.v. infusion of nitroxide probes. With this resonator and rapid scan EPR system, 4 ms scans were acquired in forward and reverse directions so that images with 2-scan 3,136 projections were acquired in 25 s. Head images were achieved with resolutions of 0.4 mm, enabling visualization of probe localization and uptake across the blood-brain barrier. This resonator design provides good sensitivity, high stability, and B1 field homogeneity for in vivo fast scan EPR of the mouse head and brain, enabling faster measurements and higher resolution imaging of probe uptake, localization, and metabolism than previously possible. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Recommanded Product: 4-Oxo-tempo).
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