Salome, Christophe published the artcileBenzofuran derivatives as a novel class of inhibitors of mTOR signaling, Recommanded Product: Piperidine-4-carboxamide, the publication is European Journal of Medicinal Chemistry (2014), 41-49, database is CAplus and MEDLINE.
High-throughput screening (HTS) hit (I) was previously identified as an inhibitor of the Akt/mTOR (Akt/mammalian target of rapamycin) signaling, which is a major target in oncol. The cytotoxicity of I was determined on a panel of human cancer cells lines with an IC50 comprised between 30 and 140 μM. Subsequent structure-activity relation (SAR) studies led us to the identification of compounds that displayed an enhanced cytotoxicity. We demonstrated also that these mols. directly bind to mTOR complex 1 (mTORC1) and inhibit its kinase activity.
European Journal of Medicinal Chemistry published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Recommanded Product: Piperidine-4-carboxamide.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem