Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds was written by Ruel, Rejean;L’Heureux, Alexandre;Thibeault, Carl;Lapointe, Philippe;Martel, Alain;Qiao, Jennifer X.;Hua, Ji;Price, Laura A.;Wu, Qimin;Chang, Ming;Zheng, Joanna;Huang, Christine S.;Wexler, Ruth R.;Rehfuss, Robert;Lam, Patrick Y. S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.HPLC of Formula: 58333-75-8 This article mentions the following:
A number of new amine scaffolds with good inhibitory activity in the ADP-induced platelet aggregation assay have been found to be potent antagonists of the P2Y1 receptor. SAR optimization led to the identification of isoindoline and piperidine derivatives which showed good in vitro binding and functional activities, as well as improved aqueous solubility Among them, the piperidine I showed the best overall profile with favorable PK parameters. In the experiment, the researchers used many compounds, for example, 4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8HPLC of Formula: 58333-75-8).
4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.HPLC of Formula: 58333-75-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem