Iron-Catalyzed Radical Activation Mechanism for Denitrogenative Rearrangement Over C(sp3)-H Amination was written by Roy, Satyajit;Das, Sandip Kumar;Khatua, Hillol;Das, Subrata;Singh, Krishna Nand;Chattopadhyay, Buddhadeb. And the article was included in Angewandte Chemie, International Edition in 2021.COA of Formula: C12H15NO3S This article mentions the following:
An iron-catalyzed denitrogenative rearrangement of 1,2,3,4-tetrazole is developed over the competitive C(sp3)-H amination. This catalytic rearrangement reaction follows an unprecedented metalloradical activation mechanism. Employing the developed method, a wide number of complex-N-heterocyclic product classes have been accessed. The synthetic utility of this radical activation method is showcased with the short synthesis of a bioactive mol. Collectively, this discovery underlines the progress of radical activation strategy that should find wide application in the perspective of medicinal chem., drug discovery and natural product synthesis research. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9COA of Formula: C12H15NO3S).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.COA of Formula: C12H15NO3S
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem