In 2018,Bioorganic & Medicinal Chemistry Letters included an article by Rong, Rui-Xue; Wang, Shan-Shan; Liu, Xuan; Li, Ren-Feng; Wang, Ke-Rang; Cao, Zhi-Ran; Li, Xiao-Liu. Quality Control of 2-(Piperidin-4-yl)ethanol. The article was titled 《Lysosomes-targeting imaging and anticancer properties of novel bis-naphthalimide derivatives》. The information in the text is summarized as follows:
A series of novel bridged bis-naphthalimide derivatives containing saturated nitrogenous heterocycles were designed and synthesized, their cytotoxic activities against Hela, MCF-7, A549 and MGC-803 cells were investigated. Compounds NI1-NI4 (I.4HCl – IV.4HCl, resp.) modified with piperidine and piperazine exhibited good and selective cytotoxic activity, for instance, compounds NI1 (IC50 2.89 and 0.60 μM) and NI4 (2.73 and 1.60 μM) showed potent cytotoxic activity against Hela cells and MGC-803 cells, resp., better than the control drug (Amonafide). However, compounds conjugated with pyrrole derivatives showed weak cytotoxic activities against the all tested cell lines. Furthermore, their DNA binding properties, fluorescence imaging and cell cycle were investigated. Interestingly, compounds NI1 and NI4 showed fluorescence enhancement because of the strong binding with Ct-DNA, and exhibited fluorescence imaging with Hela cells on the lysosomes. In the part of experimental materials, we found many familiar compounds, such as 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Quality Control of 2-(Piperidin-4-yl)ethanol)
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Quality Control of 2-(Piperidin-4-yl)ethanol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem