Romero, Donna L. et al. published their research in Journal of Medicinal Chemistry in 1996 | CAS: 50534-23-1

N-(1-Benzylpiperidin-4-yl)acetamide (cas: 50534-23-1) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 50534-23-1

Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors was written by Romero, Donna L.;Olmsted, Robert A.;Poel, Toni Jo;Morge, Raymond A.;Biles, Carolyn;Keiser, Barbara J.;Kopta, Laurice A.;Friis, Jan M.;Hosley, John D.. And the article was included in Journal of Medicinal Chemistry in 1996.Product Details of 50534-23-1 This article mentions the following:

A novel class of bis(heteroaryl)piperazine (BHAP) analogs which possesses the ability to inhibit NNRTI (non-nucleoside reverse transcriptase inhibitor) resistant recombinant HIV-1 reverse transcriptase (RT) and NNRTI resistant variants of HIV-1 was identified via targeted screening. Further investigation of the structure-activity relationships of close congeners of these novel (alkylamino)piperidine BHAPs (AAP-BHAPs) led to the synthesis of several compounds possessing the desired phenotype (e.g., activity against recombinant RTs carrying the Y181C and P236L substitutions). Further structural modifications were required to inhibit metabolism and modulate solubility in order to obtain compounds with the desired biol. profile as well as appropriate pharmaceutical properties. The AAP-BHAPs with the most suitable characteristics were compounds I and II. In the experiment, the researchers used many compounds, for example, N-(1-Benzylpiperidin-4-yl)acetamide (cas: 50534-23-1Product Details of 50534-23-1).

N-(1-Benzylpiperidin-4-yl)acetamide (cas: 50534-23-1) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 50534-23-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem