Method development and validation of fexofenadine hydrochloride in bulk and solid dosage form (tablets) by UV-visible spectrophotometry was written by Rojarani, B.;Swamy, D. Kumara. And the article was included in International Journal of Pharmacy and Pharmaceutical Research in 2022.Related Products of 153439-40-8 This article mentions the following:
A simple, accurate, and sensitive method was developed and validated for the determination of Fexofenadine hydrochloride (FEX.HCl) in bulk and tablet formulation. The method is based on the reaction of FEX.HCl with Di cyclohexyl carbodiimide (DCC) and 2-Nitrophenyl hydrazine (2-NPH) in solution, forms 2-Nitrophenyl hydrazide of Fexofenadine hydrochloride. Using ethanol as a solvent, and subsequently measured spectrophotometrically at 415nm. The reaction was extremely rapid at room temperature and absorbance values remained unchanged for at least 24h. Beer’s law was obeyed in the concentration range of 10-60μg/Ml within the detection limit of 0.62 and 0.68μg/mL and limit of quantification of 1.88 and 2.06μg/mL for FEX.HCl bulk and tablet derivatives resp. The anal. method was validated according to ICH guidelines. The correlation coefficient (r2) was found to be 0.999 and 0.998, % recovery was found to be 100.1 and 99.9, %RSD for repeatability was found to be 1.324 and 0.7824 (intraday), 1.365 and 0.7015 (interday), %RSD for intermediate precision for analyst 1 was found to be 0.435 & 0.520, for analyst 2%RSD was found to be 0.437 & 0.522 for FEX.HCl bulk and tablet derivatives resp. The robustness results of derivatives of FEX.HCl in bulk and tablets (20μg/mL) was performed by changing wavelengths and no noticeable changes were found on small changes in wavelength. Hence the method was found to be robust. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy, precision & other anal. parameters. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Related Products of 153439-40-8).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Related Products of 153439-40-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem