Thermochemistry of some derivatives of 2- and 4-piperidone was written by Ribeiro da Silva, Manuel A. V.;Cabral, Joana I. T. A.. And the article was included in Journal of Chemical & Engineering Data in 2006.Application of 3612-18-8 This article mentions the following:
Standard (p掳 = 0.1 MPa) energies of combustion for 2-piperidone, 1-methyl-2-piperidone, 1-benzyl-2-piperidone, 1-methyl-4-piperidone, 1-ethyl-4-piperidone, and 1-benzyl-4-piperidone were measured at T = 298.15 K by static bomb calorimetry. The standard molar enthalpies of formation in the condensed phase were derived. The standard molar enthalpies of vaporization at T = 298.15 K of the piperidone and derivatives studied were determined by high-temperature Calvet microcalorimetry. The resp. standard molar enthalpies of formation in the gaseous phase, at T = 298.15 K, were derived. These results are discussed in terms of mol. structure contributions. In the experiment, the researchers used many compounds, for example, 1-Ethylpiperidin-4-one (cas: 3612-18-8Application of 3612-18-8).
1-Ethylpiperidin-4-one (cas: 3612-18-8) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application of 3612-18-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem