Research on new synthetic routes about 23794-15-2

There is still a lot of research devoted to this compound(SMILES:CC(=O)C1=CC(Cl)=NC=C1)Category: piperidines, and with the development of science, more effects of this compound(23794-15-2) can be discovered.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1, published in 2010-10-01, which mentions a compound: 23794-15-2, Name is 1-(2-chloropyridine-4-yl)ethanone, Molecular C7H6ClNO, Category: piperidines.

Initial high throughput screening efforts identified highly potent and selective kappa opioid receptor antagonist 3 (κ IC50 = 77 nM; μ:κ and δ:κ IC50 ratios >400) which lacked CNS exposure in vivo. Modification of this scaffold resulted in development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides showing potent and selectivity κ antagonism as well as good brain exposure. Analog 6c (I) (κ IC50 = 20 nM; μ:κ = 36, δ:κ = 415) was also shown to reverse κ-agonist induced rat diuresis in vivo.

There is still a lot of research devoted to this compound(SMILES:CC(=O)C1=CC(Cl)=NC=C1)Category: piperidines, and with the development of science, more effects of this compound(23794-15-2) can be discovered.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem