Redzicka, Aleksandra; Czyznikowska, Zaneta; Wiatrak, Benita; Gebczak, Katarzyna; Kochel, Andrzej published an article in 2021, the title of the article was Design and synthesis of N-substituted 3,4-pyrroledicarboximides as potential anti-inflammatory agents.COA of Formula: C11H14ClNO And the article contains the following content:
The biol. activity of the newly designed and synthesized series N-substituted 3,4-pyrroledicarboximides I [R = Bu, Ph, 3-chlorophenyl; R1 = hydroxy; R2 = 1-hydroxyethyl, pyrimidin-2-yl, cyclohexyl etc.; X = C, N, O] was described. The compounds I were obtained in good yields by one-pot, three-component condensation of pyrrolo[3,4-c]pyrroles with secondary amines and an excess of formaldehyde solution in C2H5OH. The structural properties of the compounds I were characterized by 1H NMR, 13C NMR FT-IR, MS, and elemental anal. Moreover, single crystal X-ray diffraction has been recorded for compound I [R = 3-chlorophenyl; R2 = cyclohexyl; X = N]. The colorimetric inhibitor screening assay was used and obtained their potencies and inhibited COX-1 and COX-2 enzymes. According to the results, all of the tested compounds I inhibited the activity of COX-1 and COX-2. Theor. modeling was also applied to describes the binding properties of compoundsI towards COX-1 and COX-2 cyclooxygenase isoform. The data were supported by QSAR study. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).COA of Formula: C11H14ClNO
The Article related to aminomethylpyrrolopyrroledione preparation antiinflammatory docking cyclooxygenase inhibitor analgesic antioxidant, cox-1/cox-2 inhibition, mannich bases, analgesic activity, cyclic imides, docking study, inflammatory agents, pyrrolo[3,4-c]pyrrole and other aspects.COA of Formula: C11H14ClNO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem