Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Product Details of C5H11NO.
Ray, Rajdeep;Birangal, Sumit Raosaheb;Fathima, Fajeelath;Boshoff, Helena I.;Forbes, He Eun;Hariharapura, Raghu Chandrashekhar;Shenoy, G. Gautham research published 《 Molecular insights into Mmpl3 lead to the development of novel indole-2-carboxamides as antitubercular agents》, the research content is summarized as follows. Tuberculosis (TB) is an air-borne infectious disease and is the leading cause of death among all infectious diseases globally. The current treatment regimen for TB is overtly long and patient non-compliance often leads to drug resistant TB resulting in a need to develop new drugs that will act via novel mechanisms. In this research work, we selected mycobacterial membrane protein Large 3 (MmpL3) as the drug target and indole-2-carboximide as our mol. of interest for further designing new mols. A homol. model was prepared for Mycobacterium tuberculosis MmpL3 from the crystal structure of Mycobacterium smegmatis MmpL3. A series of indoles which are known to be MmpL3 inhibitors were docked in the prepared protein and the binding site properties were identified. Based on that, 10 mols. were designed and synthesized and their antitubercular activities were evaluated. We identified four hits among which the highest potency candidate possessed a min. inhibitory concentration (MIC) of 1.56 μM at 2 wk. Finally, mol. dynamics simulation studies were done with 3b and a previously reported MmpL3 inhibitor to understand the intricacies of their binding in real time and to correlate the exptl. findings with the simulation data.
5382-16-1, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., Product Details of C5H11NO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem