Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators was written by Ray, Nicholas C.;Clark, Robin D.;Clark, David E.;Williams, Karen;Hickin, H. G.;Crackett, Peter H.;Dyke, Hazel J.;Lockey, Peter M.;Wong, Melanie;Devos, Rene;White, Anne;Belanoff, Joseph K.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Reference of 58333-75-8 This article mentions the following:
A virtual screening approach comprising a 3-D similarity search based on known GR modulators was used to identify a novel series of non-steroidal glucocorticoid receptor (GR) antagonists. Optimization of the initial hit to provide potent compounds which exhibit good selectivity against other steroidal nuclear hormone receptors is described. In the experiment, the researchers used many compounds, for example, 4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8Reference of 58333-75-8).
4-(2-Methoxyphenyl)piperidine (cas: 58333-75-8) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Reference of 58333-75-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem