Rauf, Azra published the artcileSynthesis and pharmacological evaluation of novel benzoyl derivatives of piperidine-4-carboxamide, Related Products of piperidines, the publication is International Journal of Research in Pharmacy and Chemistry (2014), 4(3), 509-516, database is CAplus.
Synthesis and pharmacol. evaluation of two novel derivatives of piperidine-4-carboxamide, I (R1,R3,R5 = H; R2,R3,R4 = MeO; R2,R4 = O2N) were reported. They were synthesized by condensing the parent mol. with substituted benzoyl chlorides. The products were then assessed on different pharmacol. parameters such as analgesic, antimicrobial, antioxidant, and anxiolytic activities. It was observed that compound I (R1,R5 = H; R2,R3,R4 = MeO) displayed good analgesic profile. Both compounds possessed least to moderate antibacterial effects against tested strains of gram pos. and gram neg. bacteria. Compound I (R1,R3,R5 = H, R2,R4 = O2N) expressed moderate antifungal activity against some filamentous fungi and yeast while compound I (R1,R5 = H; R2,R3,R4 = MeO) possessed least activity for fungi only. Both compounds were inactive as antioxidants and also failed to produce remarkable change in behavior at the dose 50 mg/Kg body weight SAR was also established.
International Journal of Research in Pharmacy and Chemistry published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Related Products of piperidines.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem