Rajendraprasad, Nagaraju et al. published their research in Chemical Industry & Chemical Engineering Quarterly in 2010 | CAS: 2192-20-3

2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Computed Properties of C21H29Cl3N2O2

Acid-base titrimetric assay of hydroxyzine dihydrochloride in pharmaceutical samples was written by Rajendraprasad, Nagaraju;Basavaiah, Kanakapura;Vinay, Basavaiah Kanakapura. And the article was included in Chemical Industry & Chemical Engineering Quarterly in 2010.Computed Properties of C21H29Cl3N2O2 This article mentions the following:

Two simple titrimetric methods have been developed for the determination of hydroxyzine dihydrochloride (HDH) in pure form and in tablets. The principle of the methods are simple acid-base reactions in which the hydrochloride content of the drug was determined by titrating with an aqueous standardized NaOH solution either visually using phenolphthalein as indicator (method A) or potentiometrically using glass-calomel electrode system (method B). The methods were applicable over the range of 2-20 mg HDH. The procedures were also applied for the determination of HDH in its dosage forms and the results were found to be in good agreement with those obtained by the reference method. The precision, expressed by intra-day and inter-day relative standard deviation values, was satisfactory (RSD ≤ 2.76%). The accuracy was satisfactory as well (RE ≤ 2.67%). Excipients used as additives in pharmaceutical formulations did not interfere in the proposed procedures as shown by the recovery study via a standard addition technique with recovery percentage in the range 97.48-106.3% with a standard deviation of 1.76-3.42 %. In the experiment, the researchers used many compounds, for example, 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3Computed Properties of C21H29Cl3N2O2).

2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Computed Properties of C21H29Cl3N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics