Synthesis of Chiral Acyclic Nucleosides by Sharpless Asymmetric Dihydroxylation: Access to Cidofovir and Buciclovir was written by Qin, Tao;Li, Jian-Ping;Xie, Ming-Sheng;Qu, Gui-Rong;Guo, Hai-Ming. And the article was included in Journal of Organic Chemistry in 2018.Reference of 1928-81-0 This article mentions the following:
An efficient method to construct chiral acyclic nucleosides via Sharpless asym. dihydroxylation of N-allylpyrimidines or N-alkenylpurines is reported. A range of chiral acyclic nucleosides with two adjacent hydroxyl groups present on the side chains could be produced in good yields (up to 97% yield) and excellent enantioselectivities (90-99% ee). The synthetic utility of the reaction was demonstrated by the catalytic asym. synthesis of (S)-Cidofovir and (R)-Buciclovir. In the experiment, the researchers used many compounds, for example, 6-(Piperidin-1-yl)-9H-purine (cas: 1928-81-0Reference of 1928-81-0).
6-(Piperidin-1-yl)-9H-purine (cas: 1928-81-0) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Reference of 1928-81-0
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem