Adsorption liquid chromatography on silica for the chiral separation of amino acids and asymmetric amines derivatized with optically active N-伪-9-fluorenylmethyloxycarbonyl-amino acid-N-carboxyanhydrides was written by Pugniere, Martine;Mattras, Helene;Castro, Bertrand;Previero, Aldo. And the article was included in Journal of Chromatography A in 1997.Reference of 1722-95-8 This article mentions the following:
Optically pure N-伪-Fmoc-amino acid-N-carboxyanhydrides (Fmoc-AA-NCAs, Fmoc = 9-fluorenylmethyloxycarbonyl) are proposed as precolumn reagents for the chiral anal. of asym. amines, including 伪-amino acid alkyl esters. Separation of diastereomers arising from racemic amines was better achieved by liquid-solid adsorption chromatog. on silica than by reversed-phase techniques. Sample preparation is easily performed, and the properties of the Fmoc group allows high sensitivity by fluorescent detection. In this mode, picomolar limits of enantiomeric excess were detected. In the experiment, the researchers used many compounds, for example, (R)-2-Methylpiperidine (cas: 1722-95-8Reference of 1722-95-8).
(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Reference of 1722-95-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem