In 2019 ORG LETT published article about NUCLEOPHILIC TRIFLUOROMETHYLATION; ELECTROPHILIC AMINATION; TRANSFER HYDROGENATION; DIORGANOZINC REAGENTS; IMINES; AMINES; FLUORINE; ALKENES; ACCESS; ARYL in [Takata, Tatsuaki; Hirano, Koji; Miura, Masahiro] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan in 2019, Cited 81. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane
A copper-catalyzed regioselective net hydroamination of 1-trifluoromethylalkenes with hydrosilanes and hydroxylamines has been developed. The judicious choice of ligand and additive suppresses the conceivable but undesired beta-F elimination of an alpha-CF3-substituted organocopper intermediate, leading to targeted alpha-trifluoromethylamines in good yields with excellent regioselectivity. Additionally, with an appropriate chiral bisphosphine ligand, the enantioselective reaction is also possible to deliver optically active alpha-trifluoromethylamines of high potential in medicinal and pharmaceutical chemistry.
Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem