Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 41661-47-6, Name is Piperidin-4-one. In a document, author is Liu, Jian, introducing its new discovery. HPLC of Formula: C5H9NO.
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a] pyrazine core featuring 3-position bicyclic ring substitutes
Bruton’s tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B cell inhibition, and for the treatment of B cell related diseases. Many BTK inhibitors have been discovered for the treatment of cancer and rheumatoid arthritis, including a series of BTK inhibitors based on 8-amino-imidazo[1,5-a]pyrazine we recently reported. The X-ray crystal structures of BTK with inhibitors were also published, which provided great help for the SAR design. Here we report our SAR work introducing ring constraints for the 3-position piperidine amides on the BTK inhibitors based on 8-amino-imidazo[1,5-a]pyrazine. This modification improved the potency in BTK inhibitions, as well as the PK profile and the off-target selectivity. The dose-dependent efficacy of two BTK inhibitors was observed in the rat collagen induced arthritis (CIA) model.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 41661-47-6 help many people in the next few years. HPLC of Formula: C5H9NO.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem