One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 3040-44-6, Name is 1-(2-Hydroxyethyl)piperidine, formurla is C7H15NO. In a document, author is Wang, Tao, introducing its new discovery. Application In Synthesis of 1-(2-Hydroxyethyl)piperidine.
A New Synthetic Route to Avibactam: Lipase Catalytic Resolution and the Simultaneous Debenzylation/Sulfation
An efficient synthesis of avibactam starting from commercially available ethyl-5-hydroxypicolinate was completed in 10 steps and 23.9% overall yield. The synthesis features a novel lipase-catalyzed resolution, in the preparation of (2S,5S)-5-hydroxypiperidine-2-carboxylate acid, which is a valuable precusor of the key intermediate ethyl (2S,SR)-5-((benzyloxy)amino)-piperidine-2-carboxylate. An optimized one-pot debenzylation/sulfation reaction, followed by cation exchange, gave the avibactam sodium salt on a 400.0 g scale.
If you are hungry for even more, make sure to check my other article about 3040-44-6, Application In Synthesis of 1-(2-Hydroxyethyl)piperidine.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem