Novel 3-(4-piperidinylthio)-1H-indoles as potent nonopioid orally active central analgesics was written by Potin, Dominique;Parnet, Veronique;Teulon, Jean-Marie;Camborde, Francoise;Caussade, Francois;Meignen, Joelle;Provost, Daniel;Cloarec, Alix. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Reference of 3612-18-8 This article mentions the following:
A series of 3-(4-piperidinylthio)-1H-indoles was synthesized and evaluated in mice in the phenylbenzoquinone (PBQ)-induced writhing and hot plate tests. Most of these compounds are good analgesics with activities comparable to that of morphine. Among them UP 237-61, which has a strong serotonin binding profile, has an interesting antinociceptive activity which is not reversed by naloxone. In the experiment, the researchers used many compounds, for example, 1-Ethylpiperidin-4-one (cas: 3612-18-8Reference of 3612-18-8).
1-Ethylpiperidin-4-one (cas: 3612-18-8) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Reference of 3612-18-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem