Phytochemicals in Breast Cancer-Induced Osteoclastogenesis and Bone Resorption: Mechanism and Future Perspective was written by Pore, Subrata Kumar;Hahm, Eun-Ryeong. And the article was included in Current Pharmacology Reports in 2022.Electric Literature of C9H15NO5 This article mentions the following:
Most breast cancer patients develop bone metastasis and bone-related complications at the late stage of the disease irresp. of the subtypes. Breast cancer destroys bones by inducing osteoclastogenesis, a bone erosion process. Bisphosphonates and denosumab treatments are clin. approved but often with several limitations. Phytochems. have been shown to have anticancer properties against breast cancer especially as chemo-preventive agents. The highly promising phytochems. against breast cancer include cruciferous vegetable components (phenethyl isothiocyanate, benzyl isothiocyanate, and sulforaphane), food constituents (curcumin, piperine, and epigallocatechin gallate), and medicinal plant components (dihydroartemisinin, betulinic acid, silibinin, and plumbagin). A few of them, e.g., isothiocyanates from cruciferous vegetables are under clin. trials. These structurally diverse non-toxic phytochems. could also suppress breast cancer-induced osteoclastogenesis and bone destruction by regulating either breast cancer cells or osteoclast precursors. This review aims to discuss the mechanistic aspects and future perspective for clin. significance of these diverse phytochems. in breast cancer-induced osteoclastogenesis and osteolytic bone erosion. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2Electric Literature of C9H15NO5).
(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Electric Literature of C9H15NO5
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem