Design, synthesis and structure of new dendritic melamines. First use of a tandem C-2-substituted serinol-O,O-masked 4-piperidone as a peripheral unit in iterative synthesis was written by Popa, Flavia;Lameiras, Pedro;Moldovan, Oana;Tomoaia-Cotisel, Maria;Henon, Eric;Martinez, Agathe;Sacalis, Carmen;Mocanu, Aurora;Ramondenc, Yvan;Darabantu, Mircea. And the article was included in Tetrahedron in 2012.Application In Synthesis of 4,4′-Bipiperidine This article mentions the following:
The iterative chemoselective amination of cyanuric chloride to dimers of new G-2 dendritic N-substituted-2,4,6-triamino-s-triazines (melamines) having C-2-substituted 2-aminopropane-1,3-diols (‘serinols’) in tandem with the ethylene ketal of 4-piperidone as peripheral units is reported. The structure as a function of increasing mol. size was studied by NMR spectroscopy, DFT calculation and AFM imaging. A concise nomenclature defining the restricted rotational phenomena about the newly created C(s-triazine)-N(exocyclic) partial double bonds, seen as axes of (pro)diastereomerism, is used. We propose a new form of frontier rotamerism for the dendrimer surface, which operates over a long range. In the experiment, the researchers used many compounds, for example, 4,4′-Bipiperidine (cas: 15336-72-8Application In Synthesis of 4,4′-Bipiperidine).
4,4′-Bipiperidine (cas: 15336-72-8) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application In Synthesis of 4,4′-Bipiperidine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem