Pd-PEPPSI-IPentCl: A Highly Effective Catalyst for the Selective Cross-Coupling of Secondary Organozinc Reagents was written by Pompeo, Matthew;Froese, Robert D. J.;Hadei, Niloufar;Organ, Michael G.. And the article was included in Angewandte Chemie, International Edition in 2012.Computed Properties of C14H20BrN3O2 This article mentions the following:
A series of Pd-PEPPSI complexes with various substitution pattern on the heterocyclic carbene backbone were designed, prepared and studied as catalysts in Negishi cross-coupling reactions of aryl and heteroaryl halides or triflates with secondary organozinc nucleophiles. In all the cases, the selectivity for the normal, non-rearranged products was observed Computational studies revealed that the relative barrier difference between reductive elimination and β-hydride elimination correlate well with observed selectivities. The best results were shown by the Pd-PEPPSI-IPentcl complex which demonstrated unprecedented selectivity leading to virtually one (desired) isomer for reactions of a wide selection of alkylzincs and highly functionalized (hetero)aromatic halides and triflates. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(6-bromopyridin-2-yl)piperazine-1-carboxylate (cas: 331767-56-7Computed Properties of C14H20BrN3O2).
tert-Butyl 4-(6-bromopyridin-2-yl)piperazine-1-carboxylate (cas: 331767-56-7) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Computed Properties of C14H20BrN3O2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics