Pettenuzzo, Andrea’s team published research in Dalton Transactions in 47 | CAS: 39546-32-2

Dalton Transactions published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Safety of Piperidine-4-carboxamide.

Pettenuzzo, Andrea published the artcileAn innovative and efficient route to the synthesis of metal-based glycoconjugates: proof-of-concept and potential applications, Safety of Piperidine-4-carboxamide, the publication is Dalton Transactions (2018), 47(31), 10721-10736, database is CAplus and MEDLINE.

With a view to developing more efficient strategies to the functionalization of metallodrugs with carbohydrates, the authors here report on an innovative and efficient synthetic route to generate Au(III) glycoconjugates in high yields and purity. The method is based on the initial synthesis of the Zn(II)-dithiocarbamato intermediate [ZnII(SSC-Inp-GlcN)2] (Inp = isonipecotic moiety; GlcN = amino-glucose) followed by the transfer of the glucoseisonipecoticdithiocarbamato ligand to the Au(III) center via transmetalation reaction between the Zn(II) intermediate and K[AuIIIBr4] in 1 : 2 stoichiometric ratio, yielding the corresponding glucose-functionalized Au(II)-dithiocarbamato derivative [AuIIIBr2(SSC-Inp-GlcN)]. No protection/deprotection of the amino-glucose scaffold and no chromatog. purification were needed. The synthetic protocol was optimized for glucose precursors bearing the amino function at either the C2 or the C6 position, and works in the case of both α and β anomers. The application of the synthetic strategy was also successfully extended to other metal ions of biomedical interest, such as Au(I) and Pt(II), to obtain [AuI(SSC-Inp-GlcN)(PPh3)] and [PtII(SSC-Inp-GlcN)2], resp. All compounds were fully characterized by elemental anal., mid- and far-IR, mono- and multidimensional NMR spectroscopy, and, where possible, x-ray crystallog. Results and potential applications are here discussed.

Dalton Transactions published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Safety of Piperidine-4-carboxamide.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem