Synthesis of a Natural Product-Like Compound Collection through Oxidative Cleavage and Cyclization of Linear Peptides was written by Petersen, Rico;Le Quement, Sebastian T.;Nielsen, Thomas E.. And the article was included in Angewandte Chemie, International Edition in 2014.Product Details of 86069-86-5 The following contents are mentioned in the article:
Massive efforts in mol. library synthesis have striven for the development of synthesis methodol. which systematically delivers natural product-like compounds of high spatial complexity. Herein, the authors present a conceptually simple approach that builds on the power of solid-phase peptide synthesis to assemble precursor peptides (oligomers) designed to undergo oxidative cascade reactions. By harnessing the structural side-chain diversity and inherent stereochem. features offered by readily available amino acids (monomers), a proof-of-concept collection of 54 skeletally and stereochem. diverse compounds was generated, and selected compounds were elaborated into isoform-selective metalloprotease inhibitors. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Product Details of 86069-86-5).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Product Details of 86069-86-5
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem