Emerging pharmaceuticals and industrial chemicals in Nakdong River, Korea: Identification, quantitative monitoring, and prioritization was written by Park, Naree;Jeon, Junho. And the article was included in Chemosphere in 2021.COA of Formula: C32H39NO4 The following contents are mentioned in the article:
The extensive development and use of new anthropogenic chems. have inevitably led to their presence in aquatic environments. In the present study, the occurrence of anthropogenic substances, including pharmaceuticals and industrial chems., was investigated in one of the major rivers in Korea, the Nakdong River. Furthermore, seasonal variations in their content were determined via annual monitoring. Through the suspect and non-target screening (SNTS) technique, 58 substances were newly identified in the river and integrated in the quant. monitoring practice. The results revealed that niflumic acid and melamine exhibited the highest median concentrations, i.e., 320 ng/L and 11,000 ng/L, resp. The results associated with seasonal change revealed that the concentration of a considerable number of substances increased in winter when the flow rate was low. Some substances exhibited high concentrations in summer (e.g., polyethylene glycol) and spring (e.g., niflumic acid). This was attributed to the seasonal changes in the consumption, prescriptions, or the application of alternative substances. These changes were also reflected by the risk quotient (RQ) values calculated from the concentration and toxicity values. Pharmaceuticals such as telmisartan and carbamazepine and industrial chems. such as organophosphorus flame retardants (OPFRs) and melamine accounted for approx. 90% of the total RQ. Major substances prioritized using the production of the RQ value and the detection frequency included OPFRs and telmisartan. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0COA of Formula: C32H39NO4).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.COA of Formula: C32H39NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem