A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea was written by Pan, Jiezhou;Gong, Guidong;Wang, Qin;Shang, Jiaojiao;He, Yunxiang;Catania, Chelsea;Dan, Birnbaum;Li, Yifei;Jia, Zhijun;Zhang, Yaoyao;Joshi, Neel S.;Guo, Junling. And the article was included in Nature Communications in 2022.Computed Properties of C17H18FN3O3 This article mentions the following:
The gut microbiota represents a large community of microorganisms that play an important role in immune regulation and maintenance of homeostasis. Living bacteria receive increasing interest as potential therapeutics for gut disorders, because they inhibit the colonization of pathogens and pos. regulate the composition of bacteria in gut. However, these treatments are often accompanied by antibiotic administration targeting pathogens. In these cases, the efficacy of therapeutic bacteria is compromised by their susceptibility to antibiotics. Here, we demonstrate that a single-cell coating composed of tannic acids and ferric ions, referred to as nanoarmor, can protect bacteria from the action of antibiotics. The nanoarmor protects both Gram-pos. and Gram-neg. bacteria against six clin. relevant antibiotics. The multiple interactions between the nanoarmor and antibiotic mols. allow the antibiotics to be effectively absorbed onto the nanoarmor. Armored probiotics have shown the ability to colonize inside the gastrointestinal tracts of levofloxacin-treated rats, which significantly reduced antibiotic-associated diarrhea (AAD) resulting from the levofloxacin-treatment and improved some of the pre-inflammatory symptoms caused by AAD. This nanoarmor strategy represents a robust platform to enhance the potency of therapeutic bacteria in the gastrointestinal tracts of patients receiving antibiotics and to avoid the neg. effects of antibiotics in the gastrointestinal tract. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1Computed Properties of C17H18FN3O3).
1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Computed Properties of C17H18FN3O3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics