Heterocyclic Building Blocks-piperidine

912368-73-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.912368-73-1,(S)-tert-Butyl 3-(methylamino)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

To an ice cold stirred solution of crude (S)-tert-butyl 3-(methylamino)piperidine-1-carboxylate (3.0 g, 14 mmol) in CH2C12 (100 mL) was added Et3N (2.1 mL, 15.4 mmol),DMAP (342 mg, 2.8 mmol) and 2-bromobenzene-1-sulfonyl chloride (3.9 g, 15.4 mmol) and stirred at rt for 16 h. The reaction mixture was diluted with CH2C12 (100 mL) and washed with water. The organic layer was dried over anhydrous Na2504 and concentrated under reduced pressure. Crude product was purified with silica gel chromatography using 10%EtOAc / petroleum ether to afford 1.2 g of(S)-tert-butyl 3-(2-bromo-N-methylphenyl- sulfonamido)piperidine- 1 -carboxylate as pale yellow thick mass.LC-MS (ES+) [M +1]: 433.5.

As the paragraph descriping shows that 912368-73-1 is playing an increasingly important role.

Reference：
Patent; ORION CORPORATION; HAIKARAINEN, Anssi; KUMPULAINEN, Esa; POHJAKALLIO, Antti; PYSTYNEN, Jarmo; WANG, Shouming; (191 pag.)WO2018/2437; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5773-58-0,3-Methylpiperidin-4-one,as a common compound, the synthetic route is as follows.

1-(3-Chloropyridin-2-yl)-3-methylpiperidin-4-one was prepared by dissolving 19.2 g 3-methylpiperidin-4-one (168.9 mmol) and 25 g of Compound of Formula A (168.9 mmol) in DMSO (400 mL) under a nitrogen atmosphere to form a reaction mixture. The reaction mixture was stirred at 85 C for 12 hours. Therefter, the solvent was removed under reduced pressure. The residue was purified by column chromatography on a silica gel column, using a gradient of from 10:90 to 98:2 (by volume) ethyl acetate:hexane as an eluent, to provide 9 g of l-(3-chloropyridin-2-yl)-3-methylpiperidin-4-one., 5773-58-0

The synthetic route of 5773-58-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; EURO-CELTIQUE, S.A.; WO2005/4866; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.929252-65-3,tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

929252-65-3, E) tert-Butyl 4-((4-(2-fluoro4-(1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)-6-methoxyquinolin-7-yloxy)methyl)piperidine-1-carboxylate To a mixture of 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (15 mg, 0.06 mmol), HOBt (10 mg) and EDCI.HC1 (20 mg, 0.10 mmol) in DMF (2 mnL) was added a solution of tert-butyl 4-((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yloxy)methyl)piperidine-1-carboxylate (35 mg, 0.07 mmol) in DMF (1 mL) at rt, and the reaction mixture was stirred overnight at rt. It was directly purified by preparative HPLC to afford the product (24 mg, 56%) as a white TFA salt solid. 1H NMR (CDC13) delta12.16 (s, 1H), 8.75 (d, 1H, J=7.7 Hz), 8.64 (d, 1H, J=5.5 Hz), 8.05 (d, 1H, J=12.1 Hz), 7.83 (s, 1H), 7.67-7.24 (m, 8H), 6.72 (d, 1H, J=6.1 Hz), 6.65 (t, 1H, J=6.6 Hz), 4.22-4.11 (m, 2H), 4.07 (s, 3H), 3.48 (s, 2H), 2.78 (m, 2H), 2.13 (m, 1H), 1.87 (m, 2H), 1.47 (s, 9H), 1.35 (m, 2H).

As the paragraph descriping shows that 929252-65-3 is playing an increasingly important role.

Reference：
Patent; Bristol-Myers Squibb Company; US2007/60613; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4629-80-5,1,3-Dimethylpiperidin-4-one,as a common compound, the synthetic route is as follows.

B. Preparation of the Piperidinol The 3-bromo-i-propoxybenzene (200 g, 0.08703 mol) was combined with THF (tetrahydrofuran) (540 ml) under nitrogen and cooled to about -75 C. n-Butyllithium (565 ml, 0.8306 mol) was added dropwise while maintaining the mixture at less than -70 C. After 2 hours 1,3-dimethyl-4-piperidone (106.7 g, 0.8389 mol) was added while maintaining the temperature of the mixture between -80 C. and -70 C. After stirring for 2 hours at -70 C., the reaction mixture was then added to 6N HCl (280 ml) while maintaining the temperature at 20-25 C. The pH was adjusted to 1 with 12 N HCl. The aqueous layer was isolated and heptane (320 ml) was added to it along with 50% NaOH (48 ml, to pH of 13-14). The resulting mixture was allowed to stand overnight. The mixture was heated to 45-50 C. and the upper layer was separated. The remaining aqueous layer was extracted with heptane (320 ml) at 45-50 C. The combined organic fractions were washed with de-ionized water (120 ml) at 45-50 C. The resulting organic layer was vacuum distilled at a pot temperature of about 55 C. at 100 mmHg to remove part of the heptane. Crystallization from heptane provided 151.8 g of the named product. Melting point 75.0-76.0 C. Analysis: Calc. for (C16 H25 NO2): C, 72.97; H, 9.57; N, 5.32. Found: C, 72.87; H, 9.56; N, 5.25.

4629-80-5, Big data shows that 4629-80-5 is playing an increasingly important role.

Reference：
Patent; Eli Lilly and Company; US5136040; (1992); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

109384-19-2, tert-Butyl 4-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 82A tert-butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate The title compound was prepared as described in Example 41A substituting tert-butyl 4-hydroxypiperidine-1-carboxylate for 1-methylpiperidin-4-ol., 109384-19-2

The synthetic route of 109384-19-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Abbott Laboratories; US2010/317680; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10315-06-7, Methyl 1-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of the corresponding b-carboline-3-acid methyl ester(1 mmol), NaOH (4 mmol), C2H5OH (5 ml) and H2O (10 ml) was refluxed for 3 h, and the ethanol was removed on the rotary evaporator.The mixture was neutralized (pH = 5) with 5 N HCl and cooled. The precipitate was collected, washed well with H2O and dried in vacuum. The material was used without further purificationfor the following steps.

10315-06-7, 10315-06-7 Methyl 1-benzylpiperidine-4-carboxylate 11436222, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Wang, Jin; Wang, Zhi-Min; Li, Xue-Mei; Li, Fan; Wu, Jia-Jia; Kong, Ling-Yi; Wang, Xiao-Bing; Bioorganic and Medicinal Chemistry; vol. 24; 18; (2016); p. 4324 – 4338;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,768-66-1

n-BuLi (2.5M in hexanes, 2.27 mL, 5.67mmol) was added to cold(-50 C) anhydrous THF (20 mL) under nitrogen. 2,2, 6, 6-Tetramethylpiperidine (0.957, 0.8 g, 5.67mmol) was then added and the mixture stirred at-78 C for 30 min. A solution of the title compound of Preparation 53 (0.5 g, 2.68mmol) in THF (5 mL) was added dropwise and the mixture was stirred at-78 C for 60 min. Then, iodine (1.51 g, 5.94mmol) was added and the mixture was stirred at that temperature for 90 min and then warmed to r. t. The mixture was quenched with methanol and the residual iodine destroyed with sat. sodiumthiosulphate (aq. ). The mixture was concentrated in vacuo, partitioned between ethyl acetate and water and the organic layer was washed with water, dried and evaporated to give an oil which was purified by column cromatography (n-Hex/EtOAc 4: 1) to afford the title compound (87% yield) as an oil which crystallised. 8 (CDCI3) : 4.22 (s, 3H), 7.47 (m, 3H), 7.96 (m, 2H), 8.29 (s,1 H).

768-66-1 2,2,6,6-Tetramethylpiperidine 13035, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ALMIRALL PRODESFARMA, S.A.; WO2005/49581; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1187173-43-8, 2,7-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2,7-diazaspiro[4.5]decan-1 -one hydrochloride (0.572 g, 3mmol) and triethylamine (0.836 mL, 6.00 mmol) in dichloromethane (DCM) (15ml_), cooled in an ice-water bath, was added 4-bromo-2-(trifluoromethyl)benzenesulfonyl chloride (0.971 g, 3.00 mmol). The reaction was allowed to warm to room temperature and stirred for 18 hours.The reaction was diluted with DCM (35 ml), washed with water (30ml_), passed through a hydrophobic frit and reduced in vacuo. The residue was purified by silica chromatography (Biotage SP4) eluting with 60% EtOAc in iso-hexanes (3 column volumes), a gradient from 60-100% EtOAc (over 9 column volumes) then EtOAc (3 column volumes) to yield 7-{[4-bromo-2-(trifluoromethyl)phenyl]sulfonyl}-2,7- diazaspiro[4.5]decan-1 -one as a white solid (0.826g, 62%)1H NMR (400 MHz, Chloroform-d) d ppm 1.61 – 1 .67 (m, 1 H) 1.69 – 1 .84 (m, 3 H) 2.05 (s, 1 H) 2.43 (s, 1 H) 2.59 – 2.67 (m, 1 H) 2.85 (d, J=12.7 Hz, 1 H) 3.32 – 3.45(m, 2 H) 3.67 (d, J=12.5 Hz, 1 H) 3.80 – 3.87 (m, 1 H) 5.72 (br. s., 1 H) 7.80 – 7.88 (m, 2 H) 8.01 (d, J=1.5 Hz, 1 H)

1187173-43-8, As the paragraph descriping shows that 1187173-43-8 is playing an increasingly important role.

Reference：
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

138377-80-7, 3-Aminopiperidin-2-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 10 ; 3-[({4-[(3-chloro-2-fluorophenyl) amino]-7-methoxyquinazolin-6- yl} methyl) amino] piperidin-2-one; (Process (a)); 4- [ (3-Chloro-2-fluorophenyl) amino]-7-methoxyquinazoline-6-carbaldehyde was coupled with 3-amino-piperidin-2-one (prepared by converting 3-amino-piperidin-2-one hydrochloride to the free-base form) using an analogous method to that described for the equivalent step in Example 1 to give the title compound ; 1H NMR spectrum : (DMSO d6) 1. 5= (m, 1H), 1.68 (m, 1H), 1.84 (m, 1H), 2.16 (m, 1H), 2.73 (brs, 1H), 3.05 (dd, 1H), 3.13 (m, 2H), 3.84 (d, 1H), 3.93 (d, 1H), 3.98 (s, 3H), 7.21 (s, 1H), 7.28 (t, 1H), 7.48 (t, 1H), 7.53 (m, 2H), 8.35 (s, 1H), 8.44 (s, 1H), 9.80 (s, 1H); Mass Spectrum : (M+H) +430., 138377-80-7

The synthetic route of 138377-80-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/75439; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

321337-38-6, tert-Butyl 4-(4-(hydroxymethyl)phenoxy)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tert-butyl 4-(4-(hydroxymethyl)phenoxy)piperidine-1-carboxylate (350 mg, 1.14 mmol) in DMF (5 mL) was added sodium hydride (0.14 g, 5.7 mmol) and iodomethane (0.81 g, 5.7 mmol). The reaction was stirred at ambient temperature for 1 h. Water (20 mL) was added to the reaction vessel and the resulting biphasic mixture was extracted with DCM (3 x 50 mL). The organic phase was washed with saturated aqueous NaCl (5 x 25 mL). The combined organics were dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The resulting oil was purified by flash column chromatography with a gradient elution of hexanes (100%) to hexanes (90%) and EtOAc (10%) to provide tert-butyl 4-(4-(methoxymethyl)phenoxy)piperidine-1-carboxylate (350 mg, 1.09 mmol) as a colorless oil.

321337-38-6, 321337-38-6 tert-Butyl 4-(4-(hydroxymethyl)phenoxy)piperidine-1-carboxylate 22632413, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; SUNOVION PHARMACEUTICALS INC.; HEFFERNAN, Michele L.R.; HARDY, Larry Wendell; BROWN, Scott P.; HERMAN, Lee W.; (180 pag.)WO2018/26371; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem