Heterocyclic Building Blocks-piperidine

Piperidine was first reported in 1850 by the Scottish chemist Thomas Anderson and again, independently, in 1852 by the French chemist 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Auguste Cahours, who named it. Both of them obtained piperidine by reacting piperine with nitric acid. Synthetic Route of 5382-16-1.

Zhao, Tianming;Yang, Yu;Yang, Jing;Cui, Youbao;Cao, Zhi;Zuo, Daiying;Zhai, Xin research published 《 Harmine-inspired design and synthesis of benzo[d]imidazo[2,1-b]thiazole derivatives bearing 1,3,4-oxadiazole moiety as potential tumor suppressors》, the research content is summarized as follows. In view of the essential role of Twist1 in the tumorigenesis of NSCLC, developing antitumor small mols. that can suppress the expression of Twist1 is of far-reaching significance for the treatment of NSCLC. A series of novel benzo[d]imidazo[2,1-b]thiazole derivatives possessing 1,3,4-oxadiazole moiety I [Q = (CH₂)_n, n = 1, 2; R = 1-piperidyl, (4-methyl-1-piperidyl), (4-hydroxy-1-piperidyl), etc] was designed based on the structure of the first-in-class Twist1 inhibitor harmine. Among the synthetic twenty-two compounds, I the compound containing 2-(piperidine-1-yl) Et exhibited remarkable anti-proliferative activity with IC₅₀ value of 2.03μM and 9.80μM against A549 and H2228 cell lines superior to harmine (IC₅₀ = 17.12μM against A549, IC₅₀ = 31.06μM against H2228). Meanwhile, western blot assay showed that the optimal compound significantly down-regulated Twist1 protein expression in a dose-dependent manner and reduced Twist1 level better than harmine. Collectively, the promising compound was identified a potential antineoplastic lead with the ability of down-regulating Twist1 level.

5382-16-1, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., Synthetic Route of 5382-16-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. This gave the compound its name. 84358-13-4, formula is C11H19NO4, Name is 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid. Other examples are the fire ant toxin solenopsin, the nicotine analog anabasine of tree tobacco (Nicotiana glauca), lobeline of Indian tobacco. Application of C11H19NO4.

Zhao, Haoqiang;Xu, Xin;Yu, Haiyang;Li, Bohan;Xu, Xingyu;Li, Huanrong;Xu, Lijin;Fan, Qinghua;Walsh, Patrick J. research published 《 Rh(I)-Catalyzed C6-Selective Decarbonylative Alkylation of 2-Pyridones with Alkyl Carboxylic Acids and Anhydrides》, the research content is summarized as follows. A Rh-catalyzed chelation-assisted C6-selective C-H activation/alkylation of 2-pyridones e.g., 1-(pyridin-2-yl)-1,2-dihydropyridin-2-one with readily available anhydrides RC(O)OC(O)R (R = Me, Et, 2-methylpropyl, etc.) or alkyl carboxylic acids R¹C(O)OH (R¹ = nonyl, cyanoethyl, cyclohexyl, etc.) is introduced. The reaction proceeds via substrate decarbonylation. This approach merges C-H functionalization with readily available anhydrides, allowing for the efficient synthesis of various C6-alkylated 2-pyridones e.g., 6-methyl-2H-[1,2′-bipyridin]-2-one with good functional group tolerance.

84358-13-4, N-BOC-piperidine-4-carboxylic acid, also known asN-Boc-isonipecotic acid , is a useful research compound. Its molecular formula is C11H19NO4 and its molecular weight is 229,28 g/mole. The purity is usually 95%.

N-Boc-isonipecotic acid is a potent antitumor agent that has been clinically shown to be effective against leukemia and lymphoma. It has potent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. N-Boc-isonipecotic acid binds to the gyrase enzyme, which is used by these bacteria to maintain the integrity of their DNA, inhibiting protein synthesis and cell division. This drug also has anti-inflammatory properties. N-Boc-isonipecotic acid inhibits prostaglandin synthesis in cells, which may be due to its ability to inhibit the production of tumor necrosis factor α (TNFα) in macrophages., Application of C11H19NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 84358-13-4, formula is C11H19NO4, Name is 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Category: piperidines.

Zhang, Ziyi;Chen, Zhiguo;Zhang, Shengyu;Shao, Xiao;Zhou, Zhiwen research published 《 Antibacterial activity of the structurally novel ocotillol-type lactone and its analogues》, the research content is summarized as follows. A novel series of ocotillol-type lactone derivatives were designed and synthesized in order to study their antibacterial activity and structure-activity relationships. Among which, compounds 4j and 4 m were found to be the most active with min. inhibitory concentrations (MICs) of 1-4 μg/mL against Gram-pos. bacteria and showed low cytotoxicity against MCF-7, HEK-293 and HK-2 cells at their MICs. The antibacterial effect of compound 4 m was characterized further by SEM, cytoplasmic β-galactosidase leakage assay and UV-visible anal. The results showed that 4 m may exert its antibacterial effect by damaging bacterial cell membranes and disrupting the function of DNA, both of which could lead to rapid cell death.

84358-13-4, N-BOC-piperidine-4-carboxylic acid, also known asN-Boc-isonipecotic acid , is a useful research compound. Its molecular formula is C11H19NO4 and its molecular weight is 229,28 g/mole. The purity is usually 95%.

N-Boc-isonipecotic acid is a potent antitumor agent that has been clinically shown to be effective against leukemia and lymphoma. It has potent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. N-Boc-isonipecotic acid binds to the gyrase enzyme, which is used by these bacteria to maintain the integrity of their DNA, inhibiting protein synthesis and cell division. This drug also has anti-inflammatory properties. N-Boc-isonipecotic acid inhibits prostaglandin synthesis in cells, which may be due to its ability to inhibit the production of tumor necrosis factor α (TNFα) in macrophages., Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst: C5H5N + 3 H2 → C5H10NH. 84358-13-4, formula is C11H19NO4, Name is 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol. Quality Control of 84358-13-4.

Zhang, Zhucheng;He, Qian;Zhang, Xiaofei;Yang, Chunhao research published 《 Photoredox-catalysed regioselective synthesis of C-4-alkylated pyridines with N-(acyloxy)phthalimides》, the research content is summarized as follows. A method of direct C-4 selective alkylation of pyridines under visible light irradiation at room temperature was reported using simple maleate-derived pyridinium salts as pyridine precursors and the readily available carboxylic acid-derived N-(acyloxy)phthalimides as alkyl radical precursors, affording good to excellent yields without using stoichiometric oxidants and acids. A broad range of primary, secondary and tertiary carboxylates were used as alkylation reagents. Oxidant and acid-sensitive functional groups were tolerated well.

84358-13-4, N-BOC-piperidine-4-carboxylic acid, also known asN-Boc-isonipecotic acid , is a useful research compound. Its molecular formula is C11H19NO4 and its molecular weight is 229,28 g/mole. The purity is usually 95%.

N-Boc-isonipecotic acid is a potent antitumor agent that has been clinically shown to be effective against leukemia and lymphoma. It has potent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. N-Boc-isonipecotic acid binds to the gyrase enzyme, which is used by these bacteria to maintain the integrity of their DNA, inhibiting protein synthesis and cell division. This drug also has anti-inflammatory properties. N-Boc-isonipecotic acid inhibits prostaglandin synthesis in cells, which may be due to its ability to inhibit the production of tumor necrosis factor α (TNFα) in macrophages., Quality Control of 84358-13-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. COA of Formula: C5H11NO.

Zhang, Zhipeng;Cheng, Maojun;Guo, Jie;Wan, Yang;Wang, Rikang;Fang, Yuanying;Jin, Yi;Xie, Sai-Sai;Liu, Jing research published 《 Design, synthesis and biological evaluation of novel pyrazolone derivatives as selective butyrylcholinesterase inhibitors with antioxidant activity against Alzheimer’s disease》, the research content is summarized as follows. The pyrazolone structure was found to be a promising pharmacophore targeting BuChE. A series of pyrazolone-based compounds I (n = 2, 10, 16, etc.; R¹ = R² = Et, -(CH₂)₅-, -CHCH₃(CH₂)₄-, -(CH₂)₄-, etc.) was designed, synthesized and evaluated in vitro for BuChE inhibitory activities, antioxidant activities and blood-brain barrier (BBB) permeabilities. Besides, the compounds (n = 10, 12, 14, R¹R² = (CH₂)₅; n = 14, R¹R² = (CH₂)₄) with submicromolar IC₅₀ values as well as good BuChE selectivity were chosen to assess their cytotoxicity in PC12 cells. Compound I (n = 14; R¹R² = -(CH₂)₅-) (II) was the most selective BuChE inhibitor (SI:>200) and showed the good abilities to penetrate BBB, scavenge free radicals (1.04 trolox equivalent). Based on above results, compound (II) was selected for mol. docking studies to explain the BuChE selectivity and was considered as a promising lead compound for further investigation in the treatment of AD.

COA of Formula: C5H11NO, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., 5382-16-1.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. This gave the compound its name. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Other examples are the fire ant toxin solenopsin, the nicotine analog anabasine of tree tobacco (Nicotiana glauca), lobeline of Indian tobacco. Application In Synthesis of 5382-16-1.

Zhang, Zhe;Zhang, Zhao-Sheng;Wang, Xiao;Xi, Gao-Lei;Jin, Zhen;Tang, You-Zhi research published 《 A click chemistry approach to pleuromutilin derivatives, evaluation of anti-MRSA activity and elucidation of binding mode by surface plasmon resonance and molecular docking》, the research content is summarized as follows. A series of pleuromutilin analogs containing substituted 1,2,3-triazole moieties I [R1 = Me, Ph, 3-fluorophenyl, etc.] and II [R2 = R3 = Me, cyclohexyl, etc.] were designed, synthesized and assessed for their in vitro antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA). Initially, the in vitro antibacterial activities of these derivatives against 4 strains of S. aureus (MRSA ATCC 43300, ATCC 29213, AD3, and 144) were tested by the broth dilution method. Most of the synthesized pleuromutilin analogs displayed potent activities. Among them, compounds I [R1 = 2-methylphenyl, 2-nitrophenyl, 4-nitrophenyl] (MIC = 0.5∼1 μg/mL) showed the most effective antibacterial activity and their anti-MRSA activity were further studied by the time-killing kinetics approach. Binding mode investigations by surface plasmon resonance (SPR) with 50S ribosome revealed that the selected compounds all showed obvious affinity for 50S ribosome (K_D = 2.32 x 10^-8∼5.10 x 10^-5 M). Subsequently, the binding of compounds I [R1 = 2-methylphenyl, 4-nitrophenyl] to the 50S ribosome was further investigated by mol. modeling. Compound I [R1 = 2-methylphenyl] had a superior docking mode with 50S ribosome, and the binding free energy of compound was calculated to be -12.0 kcal/mol.

Application In Synthesis of 5382-16-1, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., 5382-16-1.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Electric Literature of 5382-16-1.

Zhang, Yuxia;Yang, Jiaxin;Meng, Tingting;Qin, Yajuan;Li, Tingyou;Fu, Junjie;Yin, Jian research published 《 Nitric oxide-donating and reactive oxygen species-responsive prochelators based on 8-hydroxyquinoline as anticancer agents》, the research content is summarized as follows. Metal ion chelators based on 8-hydroxyquinoline (8-HQ) have been widely explored for the treatment of many diseases. When aimed at being developed into potent anticancer agent, a largely unmet issue is how to avoid nonspecific chelation of metal ions by 8-HQ in normal cells or tissues. In the current work, a two-step strategy was employed to both enhance the anticancer activity of 8-HQ and improve its cancer cell specificity. Considering the well-known anticancer activity of nitric oxide (NO), NO donor furoxan was first connected to 8-HQ to construct HQ-NO conjugates. These conjugates were screened for their cytotoxicity, metal-binding ability, and NO-releasing efficiency. Selected conjugates were further modified with a ROS-responsive moiety to afford prochelators. Among all the target compounds, prodrug HQ-NO-11 was found to potently inhibit the proliferation of many cancer cells but not normal cells. The abilities of metal chelation and NO generation by HQ-NO-11 were confirmed by various methods and were demonstrated to be essential for the anticancer activity of HQ-NO-11. In vivo studies revealed that HQ-NO-11 inhibited the growth of SW1990 xenograft to a larger extent than 8-HQ. Our results showcase a general method for designing novel 8-HQ derivatives and shed light on obtaining more controllable metal chelators.

5382-16-1, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., Electric Literature of 5382-16-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. Quality Control of 2403-88-5.

Zhang, Yunfei;Niu, Junfeng;Xu, Jianhui research published 《 Fe(II)-promoted activation of peroxymonosulfate by molybdenum disulfide for effective degradation of acetaminophen》, the research content is summarized as follows. This work demonstrated that Fe ion was an effective promoter of bulk MoS₂ to activate peroxymonosulfate (PMS) to degrade acetaminophen (ACT). The ACT removal rate constant in the presence of 5 mg/L FeSO₄·7H₂O (0.1099/min) was ∼20 times that in the absence of FeSO₄•7H₂O (0.0045/min) with 0.1 g/L MoS₂/FeSO₄·7H₂O at pH₀ 3. ESR characterization and quenching experiments suggested the key role of singlet oxygen (¹O₂), acting as dominant reactive species responsible for ACT degradation in the Fe²⁺/MoS₂/PMS system. The MoS₂ chem. state and composition, ion concentrations (Fe, Mo) concentrations, and Mo⁶⁺ speciation were examined Results suggested the Fe²⁺ promoting effect originated from Fe²⁺ regeneration mediated by MoS₂, and formation of the molybdenum(VI) peroxo complex species in the Fe²⁺/MoS₂/PMS system. This work provided insight into PMS activation by MoS₂ accelerated by Fe²⁺ and suggested a highly efficient, easy-to-handle, environment-friendly method to treat refractory wastewater.

2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., Quality Control of 2403-88-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine was first reported in 1850 by the Scottish chemist Thomas Anderson and again, independently, in 1852 by the French chemist 84358-13-4, formula is C11H19NO4, Name is 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid. Auguste Cahours, who named it. Both of them obtained piperidine by reacting piperine with nitric acid. SDS of cas: 84358-13-4.

Zhang, Yanzhi;Chen, Xubing;Zhou, Yang;Hou, Jinjun;Long, Huali;Zhang, Zijia;Lei, Min;Wu, Wanying research published 《 Synthesis of oleandrin derivatives and their cytotoxic activity》, the research content is summarized as follows. A series of oleandrin-4′-yl ester derivatives, e.g. I.HCl, were designed, synthesized, and evaluated for their proliferation inhibition activities against tumor cell lines. Cytotoxicity data revealed that the C₄‘ moiety had an important influence on cytotoxic activity. Several compounds that we designed and synthesized exhibit significant in vitro antiproliferative activity against the tested tumor cell lines. Among the derivatives of OL, I.HCl not only had good antitumor activity but also had good water solubility Furthermore, I.HCl can significantly inhibit tumor growth by 96.4% at a dose of 6 mg/kg/d by i.p.

84358-13-4, N-BOC-piperidine-4-carboxylic acid, also known asN-Boc-isonipecotic acid , is a useful research compound. Its molecular formula is C11H19NO4 and its molecular weight is 229,28 g/mole. The purity is usually 95%.

N-Boc-isonipecotic acid is a potent antitumor agent that has been clinically shown to be effective against leukemia and lymphoma. It has potent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. N-Boc-isonipecotic acid binds to the gyrase enzyme, which is used by these bacteria to maintain the integrity of their DNA, inhibiting protein synthesis and cell division. This drug also has anti-inflammatory properties. N-Boc-isonipecotic acid inhibits prostaglandin synthesis in cells, which may be due to its ability to inhibit the production of tumor necrosis factor α (TNFα) in macrophages., SDS of cas: 84358-13-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Application of C5H11NO.

Zhang, Yang;Chen, Wanting;Li, Tiantian;Yan, Xiaoming;Zhang, Fan;Wang, Xiaozhou;Wu, Xuemei;Pang, Bo;He, Gaohong research published 《 A rod-coil grafts strategy for N-spirocyclic functionalized anion exchange membranes with high fuel cell power density》, the research content is summarized as follows. N-spirocyclic cations possess double-cyclic non-planar structure that exhibit the highest alkali stability among quaternary ammonium cations, however, the extremely rigidity usually causes fragile membranes and poor conductivity In this work, a rod-coil grafts design is proposed for N-spirocyclic anion exchange membranes (AEMs), in which microphase separation of the hydrophilic N-spirocyclic rod grafts is significantly improved by the hydrophobic aggregation of the flexible alkyl coil grafts with polysulfone backbone. Mol. dynamic simulations indicate that the coil grafts contribute to microphase separation but fill in free volume to reduce water reservoir, therefore the rod-coil grafts design provides a way to evaluate the effects of microphase separation and free volume on conductivity The increasing conductivity with the length of coil grafts suggests a greater contribution of good microphase separation to OH- conduction. With optimized n-octylamine hydrophobic coil graft length, the N-spirocyclic AEM exhibits toughness (elongation at break of about 28.7%) and high OH- conductivity (136.2 mS cm^-1 at 80°C), resulting in high power d. (850.1 mW cm^-2), which is far greater than that assemble with other N-spirocyclic AEMs, and also bring N-spirocyclic AEMs into the top level of the cycloaliphatic AEMs reported in literatures.

Application of C5H11NO, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., 5382-16-1.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem