Heterocyclic Building Blocks-piperidine

Schultz, Otto E. published the artcileMechanism of local anesthetic action. 1. Receptor problem, SDS of cas: 13444-24-1, the publication is Pharmazie (1970), 25(8), 472-80, database is CAplus and MEDLINE.

Furfuryl alc. was treated 1 hr at -5° with PBr3 and the product treated with MeNH2 and alc. NaI 72 hr at 100-20° to give I. Treatment of I with HBr-HOAc gave a ring-opened product which was cyclized with KOH to give 63% II. Similarly prepared were 10 other compounds including III, IV, V, VI, and VII. The local anesthetic activity of these compounds vs. procaine-HCl (III) was determined III had 80% of the VIII activity. The mechanism of local anesthetic activity is discussed.

Pharmazie published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C8H5F3O2S, SDS of cas: 13444-24-1.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Huang, Renfeng published the artcileTuning reaction pathways of peroxymonosulfate-based advanced oxidation process via defect engineering, Name: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Cell Reports Physical Science (2021), 2(9), 100550, database is CAplus.

Peroxymonosulfate (PMS)-based advanced oxidation process (AOP) has attracted great attention as an effective technique for oxidatively decomposing organic pollutants. The PMS activation mechanisms, nevertheless, are still ambiguous in many cases, and, thus, controlling PMS activation pathways for efficient pollutant removal remains challenging. In this work, taking defective PrBa0.5Sr0.5Co1.5Fe0.5O5+v (PBSCF) as a model system, we demonstrate that oxygen vacancies (V•bulo) strongly promote PMS-based AOP, and PMS activation pathways are effectively tuned. Excessive V•bulos are found to modify the surface charge distribution, change PMS adsorption configuration, and break the S-O bond of PMS. As a result, the radical process is promoted, and the predominant nonradical activation pathway shifts from an electron transfer process to singlet oxygen formation. Our mechanistic understanding can guide the rational design of catalysts for efficient water remediation.

Cell Reports Physical Science published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Name: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Huang, Xixian published the artcileMechanism Insight into Efficient Peroxydisulfate activation by Novel Nano Zero-valent Iron Anchored yCo₃O₄ (nZVI/yCo₃O₄) Composites, Safety of 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Journal of Hazardous Materials (2020), 123157, database is CAplus and MEDLINE.

Novel nano zero-valent iron anchored bio-matrix supported Co₃O₄ (nZVI/yCo₃O₄) composites were fabricated for tetracycline (TC) efficient degradation by activating peroxydisulfate (PS). The systematical characterizations verified that the nZVI/yCo₃O₄ composites with magnetism have higher surface area than yCo₃O₄ and pure Co₃O₄, contributing to more accessible active sites. Various catalytic parameters (nZVI mass ratio, leached ions, initial pH, catalyst dosage, PS concentration and coexisting anions) were thoroughly investigated. In nZVI/yCo₃O₄/PS system, 97.6%, 93.4% and 77.3% TC were degraded within 15 min at pH 3.0, 6.0 and 9.0, resp. Based on four successive degradation runs, the excellent mineralization rate and reusability of nZVI/yCo₃O₄ composites were mainly benefited from the suppressed metals leaching. The PS activated mechanisms were proposed as non-radicals (¹O₂) dominated pattern at acidic conditions and radicals (SO^{â€?/sup>-₄) predominant pattern at alk. environment, which may be highly related to the electron donating capacity of nZVI at different pH and the M(n+1)+/Mn+ redox cycling between Fe or Co metal. The plausible degradation routes of TC were presented based on the detected intermediates. Overall, the synthesized heterogeneous nZVI/yCo₃O₄ composites can efficiently active PS at a wide pH range, and further broaden the application of Co-based catalysts in PS activation.}

Journal of Hazardous Materials published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Safety of 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Zhou, Chan published the artcileEfficient activation of peroxymonosulfate on CuS@MIL-101(Fe) spheres featured with abundant sulfur vacancies for coumarin degradation: Performance and mechanisms, HPLC of Formula: 826-36-8, the publication is Separation and Purification Technology (2021), 119404, database is CAplus.

For improving the catalytic activity and recyclability of CuS in Fenton-like reaction processes, novel sulfur vacancies-enriched CuS@MIL-101(Fe) was constructed, characterized, and examined as heterogeneous catalysts for activating peroxymonosulfate (PMS) to degrade coumarin (COU). Thanks to the redox pairs of Fe3+/Fe2+, Cu+/Cu2+, S2-/S2-2/S0/sulfate species, copper-iron synergistic effect and sulfur vacancies, the CuS@MIL-101(Fe) realized a complete removal of COU (30μM) in 10 min with reaction rate constant of 0.577 min-1, which was 11.1 and 17.0 times of CuS and MIL-101(Fe), resp. The effect of various exptl. conditions (i.e., initial pH, CuS@MIL-101(Fe) dosage, PMS concentration, and background anions) on COU degradation was discussed, and the stability and versatility of CuS@MIL-101(Fe) was studied as well. Radical scavenging experiments and ESR (EPR) spectroscopy identified ·OH and 1O2 as the main reactive oxygen species (ROS). Finally, the possible mechanism of higher COU degradation efficiency in the CuS@MIL-101(Fe) activated PMS system and the degradation pathways were also deeply explored. Consequently, this work provided a novel insight into construction of sulfur vacancies-enriched heterogeneous catalysts for efficiently activating PMS for refractory organic pollutants elimination.

Separation and Purification Technology published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C10H16O2, HPLC of Formula: 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Cai, Weijie published the artcileMagnetic iron phosphide particles mediated peroxymonosulfate activation for highly efficient elimination of sulfonamide antibiotics, COA of Formula: C9H17NO, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2020), 125279, database is CAplus.

transition metal phosphides (TMP) have emerged as a promising catalyst in the environmental catalysis field due to excellent catalytic properties, high conductivity, and long stability. spherical, coral-like iron phosphide (Fe_xP) particles containing FeP orthorhombic and Fe₂P hexagonal crystals were prepared by a facile, low-temperature phosphating synthesis strategy. this heterogeneous catalyst, with unique morphol., was first used to activate peroxymonosulfate (PMS) to eliminate sulfadiazine (SDZ). Fe_xP had favorable catalytic activity to activate PMS and could eliminate SDZ up to 98.2% within 24 min. compared to Fe₂O₃ without further phosphatization treatment, P introduction in Fe₂O₃ significantly ameliorated catalytic activity for SDZ elimination; the apparent rate constant (k_obs) increased 9.1 times. Fe_xP particles exhibited a magnetic property convenient for recycling use. this feature is very different from previously reported TMP catalytic materials. four types of reactive oxygen species (sulfate radical [SO₄·^–], OH^–, singlet oxygen [¹O₂], superoxide radical [O₂^·-]) were detected and played a key role in SDZ elimination by ESR (EPR) in conjunction with radical quenching tests. results opened an avenue to develop and utilize TMP catalytic materials for environmental remediation.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, COA of Formula: C9H17NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Zhang, Xiaheng published the artcileTotal synthesis of periploside A, a unique pregnane hexasaccharide with potent immunosuppressive effects, Application of 1-(Phenylsulfinyl)piperidine, the publication is Nature Communications (2015), 5879, database is CAplus and MEDLINE.

Periploside A is a pregnane hexasaccharide identified from the Chinese medicinal plant Periploca sepium, which features a unique seven-membered formyl acetal bridged orthoester (FABO) motif and potent immunosuppressive activities. Here, we show the synthesis of this mol. in a total of 76 steps with the longest linear sequence of 29 steps and 9.2% overall yield. The FABO motif is constructed via a combination of Sinay’s and Crich’s protocol for the formation of orthoester and acetal glycosides, resp. The 2-deoxy-β-glycosidic linkages are assembled stereoselectively with judicious choice of the glycosylation methods. The epimer at the spiro-quaternary carbon in the FABO motif has also been elaborated in a stereo-controlled manner. This epimer, as well as the synthetic analogs bearing the FABO motif, retain largely the inhibitory activities of periploside A against the proliferation of T-lymphocyte, indicating the importance of the chem. connection of the FABO motif to their immunosuppressive activity.

Nature Communications published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C8H19NO2, Application of 1-(Phenylsulfinyl)piperidine.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Chen, Jianfang published the artcileSynthesis of a tetrasaccharide substrate of heparanase, Quality Control of 4972-31-0, the publication is Carbohydrate Research (2008), 343(17), 2853-2862, database is CAplus and MEDLINE.

A tetrasaccharide, corresponding to the heparan sulfate heparanase substrate, namely β-D-GlcA(2S)-(1â†?)-α-D-GlcN(NS,6S)-(1â†?)-β-D-GlcA-(1â†?)-α-D-GlcN(NS,6S)-OMe, was synthesized in a convergent manner via coupling of a pair of the disaccharide building blocks as a key step.

Carbohydrate Research published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C11H15NOS, Quality Control of 4972-31-0.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Zhao, Zhendong published the artcileConstruction of dual active sites on diatomic metal (FeCo-N/C-x) catalysts for enhanced Fenton-like catalysis, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Applied Catalysis, B: Environmental (2022), 121256, database is CAplus.

High metal loading of single-atom catalysts enables excellent catalytic activity, but possibly causes serious aggregation problem. Herein, a series of diat. FeCo-N/C-x (x represents metal content) were skillfully designed and applied to improve the catalytic activity for peroxymonosulfate (PMS) activation toward degrading organic micropollutants. The unprecedented dual active sites, referring to Fe(N₃)-Co(N₃) moiety and FeCo alloy, are constructed on the obtained FeCo-N/C-x, thereby exhibiting significantly greater performance toward degrading aqueous phenol (e.g., 0.316 min^-1 for FeCo-N/C-3) via PMS activation, compared with those of traditional single-atom Co-N/C (0.011 min^-1) and Fe-N/C (0.018 min^-1). Combined exptl. and theor. calculations demonstrate the independent functions of dual active sites, in which Fe(N₃)-Co(N₃) and FeCo alloy can decrease the energy barrier of O-O bond cleaving resulting in the formation of high-valent FeCo=O reactive species and singlet oxygen, resp. This study opens up a new platform toward constructing dual active sites for enhanced Fenton-like catalytic activity.

Applied Catalysis, B: Environmental published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C12H9N3O4, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Chen, Chen published the artcileBoron regulates catalytic sites of biochar to enhance the formation of surface-confined complex for improved peroxydisulfate activation, Name: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Chemosphere (2022), 134690, database is CAplus and MEDLINE.

Biochar has been developed to activate persulfate for wastewater treatment due to its carbon essence, easily-available and low-cost. Efficiently active sites and interfacial electron transfer are highly desired for peroxydisulfate (PDS) activation. In this study, boronic ester structure and defect degree of boron-doped biochar are confirmed as activate sites to improve PDS activation. The performance of pollutants degradation is proven to have structure-activity relationships with both activate sites. Moreover, boron-doped biochar exhibits higher stability and oxidation potential by forming the surface-confined complex, promoting electron transfer from pollutants to complex. The optimized boron-doped biochar has the advantages of adapting to a broad pH range (2.9-10.0), strong resistance to Cl_– and organic matters, a low activation energy of 11.22 kJ mol^-1, and achieving the decomposition of practical dyeing wastewater. Our work provides a promising approach to regulating the interfacial catalytic sites of biochar by doping heteroatom for PDS activation in practical wastewater treatment.

Chemosphere published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Name: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Chen, Xuan published the artcilePMS activation by magnetic cobalt-N-doped carbon composite for ultra-efficient degradation of refractory organic pollutant: Mechanisms and identification of intermediates, HPLC of Formula: 826-36-8, the publication is Chemosphere (2022), 287(Part_1), 132074, database is CAplus and MEDLINE.

Refractory organic pollutant effluent has led to severe water pollution. In this study, magnetic Co-N-doped carbon hybrid catalysts (Co-NC-x) were fabricated using a facile cation exchange combined pyrolysis and self-reduction technique to activate peroxymonosulfate (PMS) for rehabilitation of the water environment. Factors affecting the catalytic activity of the Co-NC-850 were comprehensively examined 100% of RhB degradation efficiency within 20 min was achieved in the Co-NC-850/PMS system at the optimum conditions (C0 = 80 mg L-1, catalyst loading 0.025 g L-1, PMS concentration 0.8 mM, native pH and 25 °C). The ESR measurements and competitive quenching tests demonstrated that a sulfate radical (SO4â€?) and singlet oxygen (1O2) account for RhB degradation in the Co-NC-850/PMS system, and 1O2 contributed âˆ?6.2% to RhB removal. The synergistic effect of Co0 nanoparticles (NPs) and NC on Co-NC-850 might induce a predominant non-radical route to trigger PMS activation for RhB degradation Direct oxidation of O2â€? by a hydroxyl radical (•OH) might be the crucial process for forming 1O2. Magnetic response and successive cycles verified that Co-NC-850 has superior separable performance and reusability. This innovative magnetic Co-NC-850 hybrid catalyst for PMS activation delivered vast potential for disintegration of refractory organic contaminants.

Chemosphere published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, HPLC of Formula: 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem