Heterocyclic Building Blocks-piperidine

24228-40-8, Ethyl N-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,24228-40-8

To a 50 mL round-bottomed flask was added ethyl isonipecotate (5.0 g, 32 mmol) in dimethylformamide at 0 C. Sodium hydroxide (0.86 g, 35 mmol) was added and the reaction mixture was allowed to stir for 15 minutes. 1-(Bromomethyl)benzene (4.2 ml, 35 mmol) was then added and the reaction mixture was allowed to stir slowly warming to room temperature. Upon completion, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic extract was washed with water, saturated sodium chloride solution, dried with magnesium sulfate, filtered, and concentrated. The ethyl 1-benzylpiperidine-4-carboxylate product (5.8 g, 23.3 mmol) was then added to a 500 mL round-bottomed flask in THF at -78 C. Methyllithium (18.7 ml, 46.7 mmol) was added and allowed to stir slowly warming to room temperature overnight. Upon completion, the reaction mixture was concentrated. The residue was diluted with water and extracted with ethyl acetate. The organic extract was washed with saturated sodium carbonate solution, saturated sodium chloride solution, dried with magnesium sulfate, filtered, and concentrated. The crude product was adsorbed onto a plug of silica gel and chromatographed through a Biotage pre-packed silica gel column (40M) X2, eluting with a gradient of 1% to 10% methanol in dichloromethane, to provide 2-(1-benzylpiperidin-4-yl)propan-2-ol. To a solution of 2-(1-benzylpiperidin-4-yl)propan-2-ol in methanol was added palladium, 10 wt. % on activated carbon. A hydrogen balloon was attached to the reaction vessel and the reaction mixture was stirred overnight. Upon completion, the reaction mixture was filtered through Celite. The filtrate was concentrated to produce 2-(piperidin-4-yl)propan-2-ol.

The synthetic route of 24228-40-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hu, Essa; Kunz, Roxanne; Chen, Ning; Nixey, Tom; Hitchcock, Stephen; US2009/62277; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

158407-04-6, tert-Butyl 4-(bromomethyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-hydroxy-2-methyl-6-phenoxy-9H-xanthen-9-one (33b) (100 mg, 0.31mmol), 4-bromomethyl- 1 -(tert-butoxycarbonyl)piperidine (35a) (262 mg, 0.94 mmol), K2C03 (47.8 mg, 0.35 mmol), and KI (5 mg) in IVIEK (3 mL), was heated at 70 C for 16h. The reaction was then cooled to room temperature, diluted with EtOAc, filtered and concentrated. The crude residue was filtered through a pad of silica gel, eluting with neat EtOAc to give 2-methyl-4-(( 1 -(tert-butoxycarbonyl)piperidin-4-yl)methoxy)-6-phenoxy- 9H-xanthen-9-one (35b) (159 mg, 99%), that was used directly as is in the next step.

158407-04-6, 158407-04-6 tert-Butyl 4-(bromomethyl)piperidine-1-carboxylate 15512811, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; AUCKLAND UNISERVICES LIMITED; MARSHALL, Andrew James; BUCHANAN, Christina Maree; REWCASTLE, Gordon William; LU, Guo-Liang; FLANAGAN, Jack Urquhart; BONNET, Muriel; SHEPHERD, Peter Robin; JAMIESON, Stephen Michael Frazer; GAMAGE, Swarnalatha Akuratiya; DENNY, William Alexander; (213 pag.)WO2018/83635; (2018); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1158759-03-5,tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate,as a common compound, the synthetic route is as follows.

tert-Butyl (1-(6-chloro-5-(3-chloro-2-(methylamino)isonicotinoyl)pyrazine-2-yl)-4-methylpiperidin-4-yl)methyl carbamate To a solution of Intermediate 113 (63.2 mg, 0.2 mmol) in DMF (2 mL) under N2 was added tert-butyl (4-methylpiperidin-4-yl)methyl carbamate (45.6 mg, 0.2 mmol) and K2CO3 (55.3 mg, 0.4 mmol). The resulting mixture was stirred overnight at RT and poured into H2O (20 mL). The solid that formed was removed by filtration and dried to give the title compound as a yellow solid (120 mg) which was used directly without further purification. MS (ES+) C23H30C12N6O3 requires: 508, found: 509 [M+H]+.

1158759-03-5, 1158759-03-5 tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate 70650847, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; Board of Regents, The University of Texas System; JONES, Philip; CZAKO, Barbara; CROSS, Jason; LEONARD, Paul; MSEEH, Faika; PARKER, Connor Austin; (136 pag.)US2017/342078; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

13625-39-3, 1,3,8-Triazaspiro[4.5]decane-2,4-dione is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-1 10-(oxiran-2-ylmcthyl)-2-(trifluoromcthyl)- 10//-phcnothiazinc (100 mg, 0.31 mmol) and K2CO3 (214 mg, 1.55 mmol) in DMF (10 mL) was added 1,3,8- triazaspiro[4.5]decane-2,4-dione (210 mg, 1.24 mmol), and the reaction mixture was stirred at 80 C overnight. Then the mixture was concentrated to dryness. The residue was purified by prep- HPLC (Waters XBridge C18 (50 mm x 4.6 mm, 3.5 pm); A = H2O (0.01 mol/L NH4HCO3) and B = CH3CN; 15-95% B over 8 min) to afford a white solid (41 mg, 27% yield). MT-03 la NMR (400 MHz, . -DMSO) d ppm 8.69 (s, 1H), 7.36-7.34 (d, J= 7.6Hz, 1H), 7.28-7.17 (m, 4H), 7.05-6.98 (m, 2H), 5.26-5.25(d, J= 6.0 Hz, 1H), 4.12-4.10 (m, 1H), 3.97-3.92(m, 2H), 3.45-3.43(m, J= 6.4 Hz , 2H), 2.84-2.64 (m, 4H), 1.95 (s, 1H), 1.67-1.63 (m, 2H); 1.40-1.32 (m, 2H); LC-MS: Rt = 1.63 min; ESI m/z 493 [M+lf.

13625-39-3, As the paragraph descriping shows that 13625-39-3 is playing an increasingly important role.

Reference£º
Patent; CAMP4 THERAPEUTICS CORPORATION; BUMCROT, David, A.; SEHGAL, Alfica; HERTZOG, Donald L.; (172 pag.)WO2019/195789; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3970-68-1, 4-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Compound 3 (350 mg, 3 mmol) and Compound 4 (1.28 g, 3.5 mmol) in MeCN (15 mL) was added Et3N (2 mL) at rt. The mixture was stirred at rt for 1 h. The reaction mixture was dissolved with EA (150 mL) and washed with brine (70 mL * 2). The organic layer were dried over Na2S04, concentrated in vacuo and purified by silica chromatography gel to give the desired product (652 mg, 48.7 %). *H NMR (Methanol-d4 400MHz): 8.43-8.41 (dd, J=6.5, 2.4 Hz, 1H), 8.27-8.25 (m, 1H), 7.65-7.60 (m, 2H), 7.55-7.50 (dd, J=9.8, 8.8 Hz, 1H), 3.60-3.57 (m, 2H), 3.04-2.97 (m, 2H), 1.68-1.63 (m, 4H), 1.22 (s, 3H). LCMS: 447.0 [M+l].

3970-68-1, As the paragraph descriping shows that 3970-68-1 is playing an increasingly important role.

Reference£º
Patent; NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.; WO2013/96744; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79421-45-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79421-45-7,1-(4-Nitrophenyl)piperidin-4-ol,as a common compound, the synthetic route is as follows.

Step: 3A-2Synthesis of l-(4-Amino-phProcedure:Pd-C (150mg) was added to a stirred solution of l-(4-Nitro-phenyl)-piperidin-4-ol (1.4g, 0.00630mol) in MeOH (5ml) under nitrogen atmosphere and then hydrogen gas was passed. The reaction was monitored by the TLC (10% MeOH: CHC13). The resultant was filtered and concentrated to afford 1.15g (96% yield) of l-(4-Amino-phenyl)-piperidin-4-ol.

The synthetic route of 79421-45-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara; WO2012/59932; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142374-19-4,tert-Butyl 4-(2-oxoethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

142374-19-4, To a solution of tert-butyl 4-(oxoethyl)piperidine-l-carboxylate as obtained in step 1 in dichloromethane (50 mL) was added DAST (1.2 g, 7.8 mmol) at 0 0C. The reaction mixture was warmed to room temperature and stirred for 17 h. A 5% aqueous solution of sodium bicarbonate was added and the layers were separated. The organic layer was washed with saturated sodium bicarbonate, and brine, dried over sodium sulfate, filtered and concentrated to provide tert-butyl 4-(2,2-difluoroethyl)piperidine-l-carboxylate that was used directly without further purification.

As the paragraph descriping shows that 142374-19-4 is playing an increasingly important role.

Reference£º
Patent; EXELIXIS, INC.; AAY, Naing; ARCALAS, Arlyn; BOWLES, Owen, Joseph; BUSSENIUS, Joerg; CURTIS, Jeffry, Kimo; DEFINA, Steven, Charles; DUBENKO, Larisa; HARRIS, Jason, R.; JACKSON-UGUETO, Eileen, E.; MANALO, Jean-Claire, Limun; KIM, Angie, Inyoung; PACK, Michael; PETO, Csaba, J.; RICE, Kenneth, D.; TSANG, Tsze, H.; WO2010/138487; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.475058-41-4,(S)-3-Hydroxypiperidine hydrochloride,as a common compound, the synthetic route is as follows.

(A) N8-[4-(tert-Butyl)-1,3-thiazol-2-yl]-2-[(3S)-3-hydroxyhexahydro-1-pyridinyl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide Reactions were performed in the same manner as in Example 8, (E) by using N8-[4-(tert-butyl)-1,3-thiazol-2-yl]-2,4-dioxo-3,4-dihydro-2H-pyrido[1,2-a]pyrimidine-8-carboxamide (600 mg, 1.74 mmol) and (S)-(-)-3-hydroxypiperidine hydrochloride (360 mg, 2.61 mmol) to obtain 463 mg (62%) of the title compound. 1H-NMR (CDCl3) delta: 1.35 (9H, s), 1.59 (1H, brd), 1.73-1.99 (3H, m), 3.61 (3H, m), 3.93 (2H, m), 5.71 (1H, s), 6.61 (1H, s), 7.31 (1H, d, J=7.32 Hz), 7.77 (1H, s), 8.89 (1H, d, J=7.32 Hz) EI/MS; m/s: 428 (M++1)

475058-41-4, Big data shows that 475058-41-4 is playing an increasingly important role.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD; US2003/92720; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.957855-54-8,4-Amino-2-fluoro-N-(1-methylpiperidin-4-yl)benzamide,as a common compound, the synthetic route is as follows.

957855-54-8, General procedure: Dimethyl (4-aminobenzyl)phosphonate (1.1 equiv), X-phos (0.1equiv) and Cs2CO3 (3.0 equiv) in 1,4-dioxane, and Pd(AcO)2 (0.05equiv) were added to solutions of compounds 10a-h (1 equiv) undera nitrogen atmosphere. The mixture was purged with nitrogenfor 5 min and then heated at 90 C until the reactionwas complete.The mixture was diluted with ethyl acetate, and the organic layerwas washed with saline, dried over anhydrous Na2SO4, filtered andconcentrated. The residue was purified using column chromatographyto afford compounds 11a-h.

The synthetic route of 957855-54-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Yixuan; Cheng, Maosheng; Hao, Chenzhou; Wang, Ruifeng; Wu, Tianxiao; Yang, Bowen; Yu, Sijia; Zhao, Dongmei; Zhao, Xiangxin; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

503614-91-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.503614-91-3,Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate,as a common compound, the synthetic route is as follows.

Intermediate-E (35g, 0.0716 moles) is suspended in 30 % aq. ammonia solution. Mixture was heated to 80-90C in an autoclave. Aqueous ammonia develops in- build pressure ofl-2 kg. Progress of the reaction is monitored on TLC/HPLC. When reaction was completed in -l0 hrs, reaction mass is cooled to RT and diluted with water. Product is filter and washed with water, dried at 60-65 c to obtain crude apixaban 23-25 gm with HPLC purity 98.5%. This crude product contains acid impurity approx-1.0-l.5%. Crude apixaban is further dissolved in MDC and washed with 2.0-5.0% bicarbonate solution. MDC layer is then concentrated under reduced pressure and crystallize using mixture of solvents methanol water to obtain pure apixaban with l-IPLC purity >99% (yield 6 1%).

503614-91-3 Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 22240488, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; WANBURY LTD.; NITIN SHARADCHANDRA PRADHAN; SACHIN ULHAS SONAVANE; DAYAGHAN GHANGADHAR PATIL; UTTAM SAKHARAM PUJARI; RAVINDRA BHAUSAHEB PAGIRE; WO2015/111073; (2015); A3;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem