Heterocyclic Building Blocks-piperidine

34622-39-4, (S)-2-Piperidinone-6-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(b) (S)-6-Hydroxymethyl-piperidin-2-one To a solution of (S)-6-oxopiperidine-2-carboxylic acid (17 g, 120 mmol) in methanol (200 mL) was added thionyl chloride (87 mL, 1.2 mol) and the reaction mixture was stirred at RT overnight, concentrated, combined with the product of a similar preparation, washed with saturated aqueous NaHCO3, and extracted with EtOAc (4*200 mL). The organic layers were combined, dried over sodium sulfate and evaporated to provide crude (S)-methyl 6-oxopiperidine-2-carboxylate (36.5 g).

34622-39-4, 34622-39-4 (S)-2-Piperidinone-6-carboxylic acid 11126383, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; McKinnell, Robert Murray; Long, Daniel D.; US2013/287731; (2013); A1;,
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14691-88-4, 4-Amino-2,2,6,6-tetramethylpiperidine 1-Oxyl is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of this acid (110 mg, 0.296 mmol, crude) in dry DCM (3.5 mL) at 0 C. were added successively a solution of 4-amino-TEMPO (78.4 mg, 0.444 mmol) in dry DCM (0.5 mL), DMAP (40.2 mg, 0.326 mmol), HOBt.H2O (44.0 mg, 0.326 mmol) and EDCI (69.5 mg, 0.355 mmol). The resulting orange solution was stirred at room temperature under argon for 13 h, and then washed with sat. NH4Cl. The aqueous phase was separated and extracted once with DCM, and the combined organic layers were dried (Na2SO4), filtered and concentrated in vacuo. Flash chromatography (SiO2, EtOAc to 97:3, EtOAc/MeOH) afforded 91.2 mg (59%) of the title compound as an orange oil which solidified very slowly upon high vacuum. mp 168.0-168.8 C. (softening point: -75 C.); [alpha]D23 -14.1 (c 0.5, DCM); EIMS m/z 525 ([M+H]+, 10), 371 (27), 218 (28), 201 (74), 124 (100), 91 (35), 84 (26); HRMS (EI) n/z calcd for C30H43N3O3P 524.3042, found 524.3040., 14691-88-4

As the paragraph descriping shows that 14691-88-4 is playing an increasingly important role.

Reference£º
Patent; University of Pittsburgh – Of the Commonwealth System of Higher Education; Epperly, Michael W.; Gao, Xiang; Greenberger, Joel S.; Li, Song; Wipf, Peter; (63 pag.)US2019/210969; (2019); A1;,
Piperidine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2971-79-1,Methyl piperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: A mix of methyl piperidine-4-carboxylate or ethyl 2-(piperidin-4-yl)acetate (10 mmol) in acetonitrile (20 ml), 1a-j (11 mmol),anhydrous K2CO3 (12 mmol) was refluxed under nitrogen for 8 hat 85 C. The mixture was then cooled and filtered and the solvent removed in vacuum. The residue was dissolved in ethyl acetate(50 ml) and washed with water (15 ml). Drying and removal of the solvent followed by chromatography (ethyl acetate/petroleumether = 1:4) afforded desired product 2a-j.

2971-79-1, 2971-79-1 Methyl piperidine-4-carboxylate 424914, apiperidines compound, is more and more widely used in various.

Reference£º
Article; Wang, Jin; Wang, Zhi-Min; Li, Xue-Mei; Li, Fan; Wu, Jia-Jia; Kong, Ling-Yi; Wang, Xiao-Bing; Bioorganic and Medicinal Chemistry; vol. 24; 18; (2016); p. 4324 – 4338;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.157327-41-8,1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine,as a common compound, the synthetic route is as follows.

A mixture of 1-tert-butoxycarbonylpiperidine-4-one and N,N-dimethylformamide dimethylacetal was stirred for 6 hours heated to reflux to give 1-tert-butoxycarbonyl-3-[(dimethylamino)methylene]piperidine-4-one. A mixture of the obtained 1-tert-butoxycarbonyl-3-[(dimethylamino)methylene] piperidine-4-one, 2-hydrazinoethanol and MeOH was stirred for two hours heated to reflux to give a mixture of 2-(5-tert-butoxycarbonyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-2-yl)ethanol and 2-(5-tert-butoxycarbonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-yl)ethanol. A mixture of the obtained mixture, 4M HCl-EtOAc solution and EtOH was stirred for two hours at room temperature to give a mixture of 2-(4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-2-yl)ethanol dihydrochloride and 2-(4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c] pyridine-1-yl)ethanol dihydrochloride. ES-MS(+) : 168, 157327-41-8

157327-41-8 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine 53395404, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; Astellas Pharma Inc.; EP1806347; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10315-07-8,1-Benzylpiperidine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: A 20 mL Radleys Carousel screw-capped glass tube was charged with carboxylic acid (2 mmol, 1.0 equiv), DMF (1.2 mL), T3P in DMF 50%(1.28 mL, 1.4 g, 1.1 equiv) and HCl (4 M in dioxane, 0.25 mL, 1.0mmol, 0.5 equiv) at r.t. The mixture was heated to 130 C (ca. 120 C internal) and stirred until the conversion according to LC-MS or TLCwas ?95%. The solution was quenched at 10 C with aq half-saturated Na2CO3 (5 mL; caution: gas evolution) and extracted with i-PrOAc (10mL and 2 ¡Á 5 mL or until no product was present in the aqueousphase). Combined organic phases were dried over MgSO4 and concentratedunder reduced pressure. The crude product was purified bychromatography on silica gel as described below. 1-Benzyl-N,N-dimethylpiperidine-4-carboxamide (17)The reaction was performed according to the general procedure with1-benzylpiperidine-4-carboxylic acid as starting material. Afterwork-up, the crude material was absorbed on Celite, concentrated todryness and purified by chromatography on silica gel (5 g Isolute SPEcolumn, Flash Si II; heptane-EtOAc, 4:1 to 1:9) to give 17.Yield: 450 mg (91%) yellow solid; mp 83.5-84.5 C.IR: 2926 (m), 1730 (w), 1635 (s), 1493 (m), 1341 (m), 1266 (m), 1139(m), 997 (m), 789 (w) cm-1. 1H NMR (500 MHz, CDCl3): delta = 7.31-7.35 (m, 4 H), 7.23-7.28 (m, 1 H),3.53 (s, 2 H), 3.05 (s, 3 H), 2.95 (m, 5 H), 2.49 (tt, J = 3.7, 11.4 Hz, 1 H),2.02 (t, J = 11.4 Hz, 2 H), 1.85-1.93 (m, 2 H), 1.68 (d, J = 12.9 Hz, 2 H).13C NMR (125 MHz, CDCl3): delta = 175.09, 138.45, 129.09, 128.19,126.96, 63.27, 53.21, 38.93, 37.06, 35.61, 28.53.MS: m/z = 247.16 [M + 1]+.HRMS (ESI): m/z [M + H]+ calcd for C15H22N2O: 247.1805; found:247.1809., 10315-07-8

10315-07-8 1-Benzylpiperidine-4-carboxylic acid 4714983, apiperidines compound, is more and more widely used in various.

Reference£º
Article; Bannwart, Linda; Abele, Stefan; Tortoioli, Simone; Synthesis; vol. 48; 13; (2016); p. 2069 – 2078;,
Piperidine – Wikipedia
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31140-42-8, 3-Boc-Amino-2,6-dioxopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tert-butyl (2-78, 2,6-dioxopiperidin-3-yl)carbamate (1.0 g, 4.38 mmol) in THF (15 mL) was added NaH (263 mg, 6.57 mmol) at 0 C. After stirring for 20 minutes at room temperature, iodomethane (327 muL, 5.26 mmol) was added to the reaction mixture. After stirring for 2 hours, the mixture was diluted with EtOAc and quenched with water. The organic layer was collected and the aqueous layer was washed with EtOAc. The combined organic layers were dried over Na2SO4, filtered and concentrated. The crude compound 2-79 was carried forward in the next step without additional purification., 31140-42-8

The synthetic route of 31140-42-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DANA FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael; JANG, Jaebong; DE CLERCQ, Dries; ECK, Michael; (201 pag.)WO2017/185036; (2017); A1;,
Piperidine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.167757-45-1,Benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate,as a common compound, the synthetic route is as follows.,167757-45-1

General procedure: To a solution of the aldoxime or the amide (1.0 mmol) and Et3N (1.5mmol) in EtOAc (1 mL, 1 M) at r.t. was added XtalFluor-E8 (1.1 mmol)portionwise over ca. 2 min. The resulting solution was stirred at r.t.for 1 h. The reaction mixture was quenched with sat. aq Na2CO3 and extracted with CH2Cl2 (2 ¡Á 10 mL). The combined organic layers were washed with H2O and brine, dried (MgSO4), and concentrated under vacuum to afford the crude nitrile, which was purified by flash chromatography, if required.

167757-45-1 Benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate 2776131, apiperidines compound, is more and more widely used in various.

Reference£º
Article; Keita, Massaba; Vandamme, Mathilde; Paquin, Jean-Francois; Synthesis; vol. 47; 23; (2015); p. 3758 – 3766;,
Piperidine – Wikipedia
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87120-72-7, tert-Butyl 4-aminopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

87120-72-7, Method G:Example G-1 : [1 -(4-Acryloylamino-benzenesulfonyl)-piperidin-4-yl]-carbamic acid benzyl ester4-Benzyloxycarbonylamino-piperidine-1 -carboxylic acid tert-butyl ester[00456] Diisopropylethylamine (0.9ml, 5.5mmol) was added in one portion to a stirred solution of 4-amino-piperidine-1 -carboxylic acid tert-butyl ester (1 .0g, 5.0mmol) in THF (10ml) at room temperature. To this mixture was added benzyl chloroformate (0.78ml, 5.5mmol) drop wise and the mixture was stirred at room temperature under a nitrogen atmosphere for 18 hours. After this time the mixture was diluted with ethyl acetate (50ml) and washed with water (100ml), saturated NaHCO3 (100ml) and HCl (100ml, 2M). The organic layer was separated, dried (MgSO ), filtered and concentrated under vacuum. The resulting residue was purified by flash column chromatography (elution: 50% heptane, 50% ethyl acetate) to give the title compound (1 .2g, 73% yield) as a colourless oil. Tr = 2.08 min m/z (ES+) (M+ Na+) 357.

The synthetic route of 87120-72-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHDI, INC.; DOMINGUEZ, Celia; WITYAK, John; PRIME, Michael; COURTNEY, Stephen; YARNOLD, Christoper; BROOKFIELD, Frederick; MARSTON, Richard; MACDONALD, Douglas; WO2011/60321; (2011); A1;,
Piperidine – Wikipedia
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50606-58-1,50606-58-1, 1-Benzylpiperidin-3-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Benzyl-3-piperidine hydrochloride hydrate (1.02 g, 5.40 mmol) was suspended in methylene chloride, washed with 1 M NaOH, dried through cotton, and concentrated to give 1.02 g of free base material. The free base was dissolved in THF (40 mL) and cooled to 0 C. Phenyl magnesium bromide (3.0 M in ether, 8.10 mmol, 2.70 mL) was added dropwise over 30 min, at which point the solution was warmed to rt and stirred for 3 h. The mixture was then concentrated and the residue dissolved in methylene chloride. The resultant solution was washed with 10% saturated NH4Cl, dried through cotton and concentrated. Silica gel chromatography eluding with hexanes/ethyl acetate (3:1) gave 0.975 g of the title compound as a pale yellow oil.

50606-58-1 1-Benzylpiperidin-3-one hydrochloride 3084924, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; Pfizer Inc; US2006/19975; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29608-05-7,4-(Piperidin-1-ylmethyl)aniline,as a common compound, the synthetic route is as follows.

Example 84 (Production of Compound 84) To 3-benzyloxybenzoic acid (800 mg) dissolved in THF (10 ml) were added oxalyl chloride (397 mul) and one drop of DMF, and the resulting mixture was stirred at room temperature for one hour. After the reaction mixture was evaporated to remove the solvent, to the residue dissolved in THF (15 ml) were added dropwise at room temperature 1-(4-aminobenzyl)piperidine (733 mg) and triethylamine (589 mul). This reaction mixture was stirred at room temperature for 17 hours, was then mixed with water (100 ml) and was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated solution of sodium chloride, was dried with anhydrous sodium sulfate and was then evaporated under reduced pressure to remove the solvent. The resulting residue was recrystallized from ethyl acetate/hexane to obtain 3-benzyloxy-4′-(piperidinomethyl)benzanilide (compound 84) (1.06 g) as colorless crystals., 29608-05-7

The synthetic route of 29608-05-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US6627651; (2003); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem